Effect of fluid resuscitation with albumin on mortality in patients with severe burns: A nationwide inpatient data analysis

IF 3.2 3区医学 Q2 CRITICAL CARE MEDICINE

Burns Pub Date : 2024-08-04 DOI:10.1016/j.burns.2024.07.031

Kazuha Nakamura, Toshiaki Isogai, Hiroyuki Ohbe, Mikio Nakajima, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga

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引用次数: 0

Abstract

The present study aimed to evaluate the effect of albumin administration on mortality in patients with severe burns. We retrospectively analyzed data from the Diagnosis Procedure Combination Database, a nationwide inpatient database in Japan. We identified patients in the database aged ≥ 15 years who were admitted with severe burns (burn index ≥15) from April 2014 to March 2021. We included patients who received albumin within 2 days of admission in the albumin group and those who did not in the control group. The outcome was the 28-day mortality. Eligible patients (n = 2492) were categorized into an albumin group (n = 1128) or a control group (n = 1364). One-to-one propensity score matching generated 530 pairs of patients with and without albumin administration. The 28-day mortality did not differ significantly between the two groups (albumin vs. control, 21.7 % vs. 22.8 %; risk difference, −1.1 %; 95 % confidence interval, −6.1 % to +3.9 %). These results suggest that albumin administration within 2 days of admission in patients with severe burns may not be associated with mortality during the acute phase.

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使用白蛋白进行液体复苏对严重烧伤患者死亡率的影响：全国住院患者数据分析

本研究旨在评估白蛋白用药对严重烧伤患者死亡率的影响。我们回顾性分析了日本全国住院患者数据库--诊断程序组合数据库中的数据。我们在数据库中识别了 2014 年 4 月至 2021 年 3 月期间因重度烧伤（烧伤指数≥15）入院的年龄≥15 岁的患者。我们将入院 2 天内接受白蛋白治疗的患者纳入白蛋白组，将未接受白蛋白治疗的患者纳入对照组。研究结果为 28 天死亡率。符合条件的患者（n = 2492）被分为白蛋白组（n = 1128）或对照组（n = 1364）。一对一倾向评分匹配产生了 530 对服用白蛋白和未服用白蛋白的患者。两组患者的 28 天死亡率差异不大（白蛋白组与对照组相比，21.7% 对 22.8%；风险差异为-1.1%；95% 置信区间为-6.1% 到 +3.9%）。这些结果表明，严重烧伤患者在入院 2 天内服用白蛋白可能与急性期的死亡率无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Burns 医学-皮肤病学

CiteScore

4.50

自引率

18.50%

发文量

304

审稿时长

72 days

期刊介绍： Burns aims to foster the exchange of information among all engaged in preventing and treating the effects of burns. The journal focuses on clinical, scientific and social aspects of these injuries and covers the prevention of the injury, the epidemiology of such injuries and all aspects of treatment including development of new techniques and technologies and verification of existing ones. Regular features include clinical and scientific papers, state of the art reviews and descriptions of burn-care in practice. Topics covered by Burns include: the effects of smoke on man and animals, their tissues and cells; the responses to and treatment of patients and animals with chemical injuries to the skin; the biological and clinical effects of cold injuries; surgical techniques which are, or may be relevant to the treatment of burned patients during the acute or reconstructive phase following injury; well controlled laboratory studies of the effectiveness of anti-microbial agents on infection and new materials on scarring and healing; inflammatory responses to injury, effectiveness of related agents and other compounds used to modify the physiological and cellular responses to the injury; experimental studies of burns and the outcome of burn wound healing; regenerative medicine concerning the skin.