Paper integrated microfluidic contact lens for colorimetric glucose detection

IF 3.5 Q2 CHEMISTRY, ANALYTICAL

Sensors & diagnostics Pub Date : 2024-08-05 DOI:10.1039/d4sd00135d

Pelin Kubra Isgor, Taher Abbasiasl, Ritu Das, Emin Istif, Umut Can Yener, Levent Beker

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引用次数: 0

Abstract

Contact lenses offer a simple, cost-effective, and noninvasive method for in-situ real-time analysis of various biomarkers. Electro-chemical sensors are integrated into contact lenses for analysis of various biomarkers. However, they suffer from rigid electronic components and connections, leading to eye irritation and biomarker concentration deviation. Here, a flexible, and microfluidic integrated paper-based contact lens for colorimetric analysis of glucose was implemented. Facilitating a three-dimensional (3D) printer for lens fabrication eliminates cumbersome cleanroom process and provides a simple, batch compatible process. Due to the capillary force of the filter paper, the sample was routed to detection chambers inside microchannels, and it allowed further colorimetric detection. Paper-embedded microfluidic contact lens successfully detects glucose down to 2 mM within ~10 sec. The small dimension of the microfluidic system enables detection of glucose levels as low as 5 µl. The results show the potential of the presented approach to analyze glucose concentration in a rapid manner. It is demonstrated that the fabricated contact lens can successfully detect glucose levels of diabetic patients.

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用于比色葡萄糖检测的纸质集成微流体接触镜

隐形眼镜为原位实时分析各种生物标记物提供了一种简单、经济、无创的方法。电化学传感器被集成到隐形眼镜中，用于分析各种生物标志物。然而，这些传感器的电子元件和连接都比较僵硬，会对眼睛造成刺激，并导致生物标记物浓度偏差。在这里，我们实现了一种用于葡萄糖比色分析的柔性微流控集成纸基隐形眼镜。利用三维（3D）打印机制造镜片，省去了繁琐的洁净室流程，并提供了简单、批量兼容的工艺。由于滤纸的毛细力，样品被输送到微通道内的检测室，并可进一步进行比色检测。嵌入滤纸的微流控接触镜可在约 10 秒内成功检测出低至 2 mM 的葡萄糖。微流体系统尺寸小，可检测低至 5 µl 的葡萄糖水平。结果表明，所提出的方法具有快速分析葡萄糖浓度的潜力。结果表明，制作的隐形眼镜可以成功检测糖尿病患者的葡萄糖水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sensors & diagnostics

CiteScore

2.30

自引率

0.00%

发文量