The Efficacy and Safety of Biosimilars in Hidradenitis Suppurativa: A Comprehensive Review

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-08-12 DOI:10.2147/ccid.s478840

Eman Almukhadeb, Almuntsrbellah Almudimeegh, Khalid Nabil Nagshabandi, Yousef Luay Alsuwailem, Asem Shadid

引用次数: 0

Abstract

Abstract: Hidradenitis Suppurativa (HS), also known as Acne Inversa, is a chronic, recurrent inflammatory skin condition primarily affecting apocrine gland-bearing areas, such as the axilla and groin. Characterized by painful nodules, abscesses, and scarring, and has a profound psychological impact on patients. Current treatments aim to manage symptoms and prevent new lesions with a combination of non-pharmacological and pharmacological approaches. Emerging biosimilars, which replicate the efficacy and safety profiles of known biologics at a lower cost, offer new options for treating this debilitating cutaneous disorder. The review summarizes recent studies to explain the role of biosimilars in HS, emphasizing their potential to expand effective treatment options.

Keywords: biologics, biosimilars, hidradenitis suppurativa, review

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生物仿制药在扁平苔藓中的疗效和安全性：全面综述

摘要：化脓性扁平湿疹（Hidradenitis Suppurativa，HS）又称痤疮（Acne Inversa），是一种慢性、复发性炎症性皮肤病，主要累及腋窝和腹股沟等分泌腺丰富的部位。该病以疼痛性结节、脓肿和瘢痕为特征，对患者的心理影响深远。目前的治疗方法旨在通过非药物和药物相结合的方式来控制症状和预防新的病变。新兴的生物仿制药以较低的成本复制了已知生物制剂的疗效和安全性，为治疗这种使人衰弱的皮肤疾病提供了新的选择。本综述总结了近期的研究，解释了生物仿制药在HS中的作用，强调了其扩大有效治疗选择的潜力。关键词：生物制剂；生物仿制药；化脓性扁平苔癣；综述

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.