Multi-faceted regulation of CREB family transcription factors

IF 3.5 3区医学 Q2 NEUROSCIENCES

Frontiers in Molecular Neuroscience Pub Date : 2024-08-06 DOI:10.3389/fnmol.2024.1408949

Md Arifur Rahman Chowdhury, Md Mazedul Haq, Jeong Hwan Lee, Sangyun Jeong

引用次数: 0

Abstract

cAMP response element-binding protein (CREB) is a ubiquitously expressed nuclear transcription factor, which can be constitutively activated regardless of external stimuli or be inducibly activated by external factors such as stressors, hormones, neurotransmitters, and growth factors. However, CREB controls diverse biological processes including cell growth, differentiation, proliferation, survival, apoptosis in a cell-type-specific manner. The diverse functions of CREB appear to be due to CREB-mediated differential gene expression that depends on cAMP response elements and multi-faceted regulation of CREB activity. Indeed, the transcriptional activity of CREB is controlled at several levels including alternative splicing, post-translational modification, dimerization, specific transcriptional co-activators, non-coding small RNAs, and epigenetic regulation. In this review, we present versatile regulatory modes of CREB family transcription factors and discuss their functional consequences.

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CREB 家族转录因子的多方面调控

cAMP 反应元件结合蛋白（CREB）是一种普遍表达的核转录因子，它可以不受外界刺激的影响而构成性激活，也可以受压力源、激素、神经递质和生长因子等外界因素的影响而诱导性激活。然而，CREB 以细胞类型特异性的方式控制着细胞生长、分化、增殖、存活和凋亡等多种生物过程。CREB 的多种功能似乎是由于 CREB 介导的不同基因表达依赖于 cAMP 响应元件和 CREB 活性的多方面调控。事实上，CREB 的转录活性受多个水平的控制，包括替代剪接、翻译后修饰、二聚化、特定转录共激活因子、非编码小 RNA 和表观遗传调控。在这篇综述中，我们将介绍 CREB 家族转录因子的多种调控模式，并讨论其功能性后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Molecular Neuroscience NEUROSCIENCES-

CiteScore

5.70

自引率

2.10%

发文量

669

审稿时长

14 weeks

期刊介绍： Frontiers in Molecular Neuroscience is a first-tier electronic journal devoted to identifying key molecules, as well as their functions and interactions, that underlie the structure, design and function of the brain across all levels. The scope of our journal encompasses synaptic and cellular proteins, coding and non-coding RNA, and molecular mechanisms regulating cellular and dendritic RNA translation. In recent years, a plethora of new cellular and synaptic players have been identified from reduced systems, such as neuronal cultures, but the relevance of these molecules in terms of cellular and synaptic function and plasticity in the living brain and its circuits has not been validated. The effects of spine growth and density observed using gene products identified from in vitro work are frequently not reproduced in vivo. Our journal is particularly interested in studies on genetically engineered model organisms (C. elegans, Drosophila, mouse), in which alterations in key molecules underlying cellular and synaptic function and plasticity produce defined anatomical, physiological and behavioral changes. In the mouse, genetic alterations limited to particular neural circuits (olfactory bulb, motor cortex, cortical layers, hippocampal subfields, cerebellum), preferably regulated in time and on demand, are of special interest, as they sidestep potential compensatory developmental effects.