Optical characterization of a new composition of acrylic acid hydrogel dosimeter for quality assurance in radiotherapy treatment

IF 1.5 3区 化学 Q3 CHEMISTRY, ANALYTICAL
Khalid A. Rabaeh, Belal Moftah, Akram A. Moussa, Abdullah S. Bani Issa, Md A. Al Kafi
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Abstract

A new polymer hyrogel dosimeter based on acrylic acid in polyvinyl alcohol hydrogel matrix was prepared to be used in radiation measurments for radiotherapy treatment. The hydrogel dosimeters were exposed to ionizing radiation using a medical linear accelerator. The hydrogel samples were irradiated at 6 MV beam energy, 600 cGy min−1 dose rate, and various doses up to 50 Gy. UV–VIS Spectrophotometry was used to readout the dose response of non-irradiated and irradiated hydrogel samples at absorbance of 630 nm. The results show the dose response increases strongly with increasing abosrbed doses, with a large linear dose range (2–30 Gy) and dose sensitivity of 0.013 Gy−1 s−1. Moreover, no significant variation in dose response was obseved when the gel samples are irridiated under different dose-rates as well as radiation beam energies. A noticeble change in the stability of the irradiated hydrogel samples was found within the first three days of irradiation, followed by a high post-irradiation stability, for the next 14 days. The non-irridiated samples were stable, up to 10 weeks.

Abstract Image

用于放射治疗质量保证的丙烯酸水凝胶剂量计新成分的光学特性分析
制备了一种基于聚乙烯醇水凝胶基质中丙烯酸的新型聚合物水凝胶剂量计,用于放射治疗的辐射测量。使用医用直线加速器对水凝胶剂量计进行电离辐射照射。水凝胶样品在 6 MV 束能、600 cGy min-1 剂量率和高达 50 Gy 的不同剂量下接受辐照。使用紫外-可见分光光度法在 630 纳米的吸光度读出未辐照和辐照水凝胶样品的剂量响应。结果表明,随着辐照剂量的增加,剂量响应也随之增加,线性剂量范围较大(2-30 Gy),剂量灵敏度为 0.013 Gy-1 s-1。此外,在不同剂量率和辐射束能量下辐照凝胶样品时,剂量响应没有明显变化。辐照后的前三天内,辐照水凝胶样品的稳定性发生了明显变化,随后的 14 天内,辐照后的稳定性都很高。而未经过辐照的样品则稳定长达 10 周。
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来源期刊
CiteScore
2.80
自引率
18.80%
发文量
504
审稿时长
2.2 months
期刊介绍: An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.
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