Study of thermally induced interactions between active substances from the sartans class and various excipients

IF 3 3区工程技术 Q2 CHEMISTRY, ANALYTICAL

Journal of Thermal Analysis and Calorimetry Pub Date : 2024-08-06 DOI:10.1007/s10973-024-13477-x

Bianca-Denisa Cernușcă, Ionela-Amalia Bradu, Alexandru Pahomi, Dorinel Okolisan, Mihaela Maria Budiul, Gabriela Vlase, Titus Vlase

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引用次数: 0

Abstract

Sartans, also known as angiotensin receptor blockers, comprise a category of antihypertensive medications designed to inhibit the actions of angiotensin II (Ang II) in the body, ultimately reducing blood pressure levels. This class of compounds is derived from 2-(1-benzyl-1H-imidazol-5-yl)-acetic acid, with its origin characterized by an imidazole core that underwent various substitutions at specific positions within the heterocyclic nucleus. We investigated the behavior of Losartan, Valsartan and Irbesartan and their compatibility with various excipients used in pharmaceutical tablet formulations by FTIR spectroscopic studies, thermal behavior by thermogravimetry and differential scanning calorimetry. The aim of the study was to determine the excipients to be used in pharmaceutical formulations containing drugs from the class of sartans as active ingredients. Our study concludes by recommending precautionary measures in elaborating new solid formulations containing lactose in the case of Losartan.

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沙坦类活性物质与各种辅料之间的热诱导相互作用研究

沙坦类药物又称血管紧张素受体阻滞剂，是一类降压药，旨在抑制血管紧张素 II（Ang II）在体内的作用，最终降低血压水平。这类化合物由 2-(1-苄基-1H-咪唑-5-基)乙酸衍生而来，其起源的特点是以咪唑为核心，在杂环核的特定位置进行了各种取代。我们通过傅立叶变换红外光谱研究、热重法和差示扫描量热法研究了洛沙坦、缬沙坦和厄贝沙坦的行为及其与药物片剂中使用的各种辅料的相容性。研究的目的是确定含有沙坦类药物作为活性成分的药物制剂中应使用的辅料。我们的研究最后建议在配制含有乳糖的新固体制剂时采取预防措施，例如洛沙坦。

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来源期刊

Journal of Thermal Analysis and Calorimetry 化学-分析化学

CiteScore

8.50

自引率

9.10%

发文量

577

审稿时长

3.8 months

期刊介绍： Journal of Thermal Analysis and Calorimetry is a fully peer reviewed journal publishing high quality papers covering all aspects of thermal analysis, calorimetry, and experimental thermodynamics. The journal publishes regular and special issues in twelve issues every year. The following types of papers are published: Original Research Papers, Short Communications, Reviews, Modern Instruments, Events and Book reviews. The subjects covered are: thermogravimetry, derivative thermogravimetry, differential thermal analysis, thermodilatometry, differential scanning calorimetry of all types, non-scanning calorimetry of all types, thermometry, evolved gas analysis, thermomechanical analysis, emanation thermal analysis, thermal conductivity, multiple techniques, and miscellaneous thermal methods (including the combination of the thermal method with various instrumental techniques), theory and instrumentation for thermal analysis and calorimetry.