Efficient Synaptic Emulation and Ultralow Power Digital-Analog Conversion in Cellulose-Based Neural Devices through Molecular Polarization

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2024-08-06 DOI:10.1021/acsmaterialslett.4c01002

Kuan-Chang Chang, Yihua Xu, Mingge Wang, Zehui Peng, Dar-Jen Hsieh, Lei Li

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Abstract

Efficient hardware–cell communication is crucial in understanding cellular states and controlling cells, serving as a crucial pathway in advancing next-generation human–machine interfaces. Here, we propose an energy-efficient neural device based on natural cellulose, addressing limitations in conventional interface communication hardware, particularly concerning material biocompatibility and biological signal matching. The cellulose-based device effectively emulates the plasticity of biological synaptic connections and exhibits learning behavior under biograde voltage as low as 10 mV. Significantly, it demonstrates exceptional digital-to-analog conversion performance with a minimal power consumption of 0.1 nJ, facilitating efficient interface biological signal matching. Furthermore, a molecular-level model is introduced to elucidate the rotation of intramolecular polar bonds in cellulose induced by electrical stimulation. This rotation alters the material’s relative dielectric constant, unveiling the digital-to-analog conversion ability and neuro-like behavior. The biocompatible cellulose-based device efficiently emulates synapses with its low-power signal conversion, holding promise for effective biological signal matching in brain–machine interfaces.

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通过分子极化实现纤维素神经器件中的高效突触模拟和超低功耗数模转换

高效的硬件-细胞通信是了解细胞状态和控制细胞的关键，也是推进下一代人机界面的重要途径。在这里，我们提出了一种基于天然纤维素的高能效神经设备，解决了传统接口通信硬件的局限性，尤其是材料的生物兼容性和生物信号匹配问题。这种基于纤维素的设备能有效模拟生物突触连接的可塑性，并在低至 10 mV 的生物级电压下表现出学习行为。值得注意的是，该器件具有出色的数模转换性能，功耗仅为 0.1 nJ，有助于实现高效的界面生物信号匹配。此外，还引入了一个分子级模型，以阐明电刺激引起的纤维素分子内极性键旋转。这种旋转改变了材料的相对介电常数，从而揭示了数模转换能力和类似神经的行为。这种基于纤维素的装置具有生物兼容性，可通过低功耗信号转换有效模拟突触，有望在脑机接口中实现有效的生物信号匹配。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.