MXene-reinforced bioactive polymer hydrogels for biomedical applications

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

APL Materials Pub Date : 2024-08-09 DOI:10.1063/5.0226665

Guanghui Gu, Xue Chen, Gang Wei, Mingjin Xu

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引用次数: 0

Abstract

MXenes, a novel class of two-dimensional (2D) materials, have attracted considerable attention in various fields, especially in drug delivery, wound healing, bone tissue engineering, biosensing, and cancer treatment. Thanks to their remarkable physicochemical properties, MXenes hold great promise for biomedical applications. Concurrently, hydrogels composed of polymers have been extensively utilized in biomedical contexts. The unique properties of MXenes facilitate their integration into various bioactive hydrogels with enhanced functions and properties, thereby endowing the composites with multifunctional capabilities. MXene-reinforced polymer hydrogels (MRPHs) synergistically combine the advantageous characteristics of both MXenes and hydrogels, making them highly adaptable for integration with other theranostic strategies in medical applications. In this comprehensive review, we demonstrate recent advances in the design and synthesis of MRPHs for biomedical applications. Specifically, we introduce the unique functions and properties of MRPHs and analyze the methods for tailoring the functions of MRPHs by incorporating them with other active components, including functional molecules, 2D materials, metal ions, natural polymers, and drugs/genes. We then discuss the biomedical applications of the designed bioactive MRPHs in wound healing, tissue engineering, biosensors, and cancer therapy. We hope that this work provides valuable guidance and inspiration for readers to develop novel MRPHs for advanced applications.

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用于生物医学应用的 MXene 增强型生物活性聚合物水凝胶

二氧杂环烯是一类新型的二维（2D）材料，在各个领域，特别是在药物输送、伤口愈合、骨组织工程、生物传感和癌症治疗等方面引起了广泛关注。由于其卓越的物理化学特性，MXenes 在生物医学应用中大有可为。与此同时，由聚合物组成的水凝胶也被广泛应用于生物医学领域。二甲亚麻烯的独特性质有助于将其整合到各种生物活性水凝胶中，增强其功能和性质，从而使复合材料具有多功能性。二甲亚甲基增强聚合物水凝胶（MRPHs）协同结合了二甲亚甲基和水凝胶的优势特性，使其在医疗应用中与其他治疗策略高度融合。在这篇综述中，我们展示了用于生物医学应用的 MRPHs 的设计和合成方面的最新进展。具体来说，我们介绍了 MRPHs 的独特功能和特性，并分析了通过将 MRPHs 与其他活性成分（包括功能分子、二维材料、金属离子、天然聚合物和药物/基因）结合来定制 MRPHs 功能的方法。然后，我们讨论了所设计的生物活性 MRPH 在伤口愈合、组织工程、生物传感器和癌症治疗方面的生物医学应用。我们希望这项工作能为读者开发新型 MRPHs 的高级应用提供有价值的指导和启发。

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来源期刊

APL Materials NANOSCIENCE & NANOTECHNOLOGYMATERIALS SCIE-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

9.60

自引率

3.30%

发文量

199

审稿时长

2 months

期刊介绍： APL Materials features original, experimental research on significant topical issues within the field of materials science. In order to highlight research at the forefront of materials science, emphasis is given to the quality and timeliness of the work. The journal considers theory or calculation when the work is particularly timely and relevant to applications. In addition to regular articles, the journal also publishes Special Topics, which report on cutting-edge areas in materials science, such as Perovskite Solar Cells, 2D Materials, and Beyond Lithium Ion Batteries.