Current progress in aptamer-based sensors for the detection of protein biomarkers in neurodegenerative diseases

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology

Biosensors and Bioelectronics: X Pub Date : 2024-08-08 DOI:10.1016/j.biosx.2024.100528

Tao Cheng , Noshin Afshan , Jianwei Jiao , Jin Jiao

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引用次数: 0

Abstract

Neurodegenerative diseases (NDs) have been a group of disorders characterized by neuronal death and functional loss including Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD), etc. Since diagnostic methods for the NDs biomarkers have been based on traditional enzyme linked immunosorbent assay (ELISA) or Western Blotting, the antibody intrinsic drawbacks such as large molecular weight and high cost make early diagnosis of NDs quite challenging. The aptamers bridge this gap effectively and their versatile features such as small molecular weight, easy modification, high stability and low cost have been widely used to fabricate biosensors to diagnose NDs. Various aptamer-based biosensors have shown excellent performance in the early diagnosis of NDs. Several biomarkers including nucleic acid, protein, biomolecule, and exosome has been used as early diagnostic indicators for NDs. In this minireview, we aim to report the latest progress in aptasensors (including colorimetric, fluorescence, electrochemical and electrochemiluminescence, etc) for detecting NDs protein biomarkers, summarize principles of their functions along with challenges in the way to diagnose NDs and emphasize their future perspectives.

查看原文本刊更多论文

基于适配体的传感器在检测神经退行性疾病蛋白质生物标记物方面的最新进展

神经退行性疾病（NDs）是一组以神经元死亡和功能丧失为特征的疾病，包括阿尔茨海默病（AD）、帕金森病（PD）和亨廷顿病（HD）等。由于 NDs 生物标记物的诊断方法一直基于传统的酶联免疫吸附试验（ELISA）或西方印迹法，抗体固有的缺点（如分子量大和成本高）使 NDs 的早期诊断变得相当具有挑战性。适配体有效地弥补了这一缺陷，其分子量小、易于修饰、稳定性高和成本低等多功能特性已被广泛用于制造诊断 NDs 的生物传感器。各种基于适配体的生物传感器在非典的早期诊断中表现出了卓越的性能。包括核酸、蛋白质、生物大分子和外泌体在内的多种生物标志物已被用作 NDs 的早期诊断指标。在这篇微型综述中，我们旨在报告用于检测 NDs 蛋白质生物标记物的相应传感器（包括比色、荧光、电化学和电化学发光等）的最新进展，总结其功能原理以及在诊断 NDs 过程中面临的挑战，并强调其未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biosensors and Bioelectronics: X Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

166

审稿时长

54 days

期刊介绍： Biosensors and Bioelectronics: X, an open-access companion journal of Biosensors and Bioelectronics, boasts a 2020 Impact Factor of 10.61 (Journal Citation Reports, Clarivate Analytics 2021). Offering authors the opportunity to share their innovative work freely and globally, Biosensors and Bioelectronics: X aims to be a timely and permanent source of information. The journal publishes original research papers, review articles, communications, editorial highlights, perspectives, opinions, and commentaries at the intersection of technological advancements and high-impact applications. Manuscripts submitted to Biosensors and Bioelectronics: X are assessed based on originality and innovation in technology development or applications, aligning with the journal's goal to cater to a broad audience interested in this dynamic field.