The theoretical and experimental studies have been carried out on the water and salt migration and deformation characteristics of sulfate saline soil during freeze-thaw cycles. Based on the theory of unsaturated soil mechanics and the thermoelastic continuum and considering the influence of phase change within the pore on thermodynamic and hydrodynamic parameters, the multi-physical fields coupled model of hydro-thermal-salt-mechanical in unsaturated sulfate saline soil has been established. The variation processes of the temperature field, water field, salt field, and stress field of the soil during freeze-thaw cycles were analyzed, and the validity of the theoretical model was verified by indoor experiments. The results show that there are significant attenuation and hysteresis effects when heat is transferred in the soil during freeze-thaw cycles. The water content of migration in the soil increases with the height of the soil column, while the increment of migration water content decreases with the number of freeze-thaw cycles. The formation and dissolution of salt crystals from top to bottom and the sudden increase in the salt crystallization rate are mainly caused by variations in the solubility of the salt solutions due to temperature changes. The formation and dissolution of ice and salt crystals in the soil induce expansion and contraction, and the freeze-thaw cycle conditions have a significant effect on the expansion and residual deformation of the soil.