Hyaluronic acid-coated silver nanoparticles releasing Doxorubicin for combinatorial antitumor therapy

IF 5.9 3区 工程技术 Q1 CHEMISTRY, MULTIDISCIPLINARY
Phuong Le Thi, Dinh Trung Nguyen, Thien An Nguyen Huu, Quang-Hieu Tran, Minh-Dung Truong, Ngo Thanh Hang, Ngoc Quyen Tran, Ki Dong Park
{"title":"Hyaluronic acid-coated silver nanoparticles releasing Doxorubicin for combinatorial antitumor therapy","authors":"Phuong Le Thi, Dinh Trung Nguyen, Thien An Nguyen Huu, Quang-Hieu Tran, Minh-Dung Truong, Ngo Thanh Hang, Ngoc Quyen Tran, Ki Dong Park","doi":"10.1016/j.jiec.2024.07.049","DOIUrl":null,"url":null,"abstract":"Although various nanocarriers have been developed to deliver anticancer drugs to the target tumors, it is still remaining great challenges, including burst release, non-specific targetability and insufficient therapeutic efficacy. Herein, we prepared a multifunctional nanoparticle composed of Ag core and hyaluronic acid shell (Ag NPs@HA) for stimultaneously intracellular delivery of Doxorubicin (DOX) and Ag NPs to improve the anticancer therapeutic efficacy. For our approach, Ag NPs was simply synthesized via the redox reaction between Ag ions and catechol group of functional HA, and DOX was subsequently loaded into the HA-coated Ag NPs through the interaction between the remaining catechol groups and DOX (Ag NPs@HA/DOX). The particles exhibited uniform morphology, good biocompatibility to normal cells, and pH-sensitive drug release. Notably, thanks to the specific interaction of HA and CD44 receptor-overexpressing cancer cells, Ag NPs@HA/DOX could dramatically improve the anti-tumor efficacy as well as mimicking 3D spheroid model, compared to the free DOX. Moreover, Ag NPs@HA/DOX exhibited superior tumor supression on a HELA-xenografted mouse model, while minimizing the systemic toxicity of free DOX. From the obtained results, we suggest Ag NPs@HA as potential nanocarrier for targeting delivery of various therapeutic drugs in anticancer therapy.","PeriodicalId":363,"journal":{"name":"Journal of Industrial and Engineering Chemistry","volume":"2 1","pages":""},"PeriodicalIF":5.9000,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Industrial and Engineering Chemistry","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.jiec.2024.07.049","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Although various nanocarriers have been developed to deliver anticancer drugs to the target tumors, it is still remaining great challenges, including burst release, non-specific targetability and insufficient therapeutic efficacy. Herein, we prepared a multifunctional nanoparticle composed of Ag core and hyaluronic acid shell (Ag NPs@HA) for stimultaneously intracellular delivery of Doxorubicin (DOX) and Ag NPs to improve the anticancer therapeutic efficacy. For our approach, Ag NPs was simply synthesized via the redox reaction between Ag ions and catechol group of functional HA, and DOX was subsequently loaded into the HA-coated Ag NPs through the interaction between the remaining catechol groups and DOX (Ag NPs@HA/DOX). The particles exhibited uniform morphology, good biocompatibility to normal cells, and pH-sensitive drug release. Notably, thanks to the specific interaction of HA and CD44 receptor-overexpressing cancer cells, Ag NPs@HA/DOX could dramatically improve the anti-tumor efficacy as well as mimicking 3D spheroid model, compared to the free DOX. Moreover, Ag NPs@HA/DOX exhibited superior tumor supression on a HELA-xenografted mouse model, while minimizing the systemic toxicity of free DOX. From the obtained results, we suggest Ag NPs@HA as potential nanocarrier for targeting delivery of various therapeutic drugs in anticancer therapy.
释放多柔比星的透明质酸涂层银纳米粒子用于组合抗肿瘤疗法
尽管目前已开发出多种纳米载体将抗癌药物递送至靶向肿瘤,但仍面临着猝发释放、非特异性靶向性和疗效不足等巨大挑战。在此,我们制备了一种由Ag核和透明质酸壳组成的多功能纳米粒子(Ag NPs@HA),用于同时在细胞内递送多柔比星(Doxorubicin,DOX)和Ag NPs,以提高抗癌疗效。在我们的研究中,Ag NPs是通过Ag离子与功能性HA的邻苯二酚基团发生氧化还原反应而合成的,随后通过剩余的邻苯二酚基团与DOX(Ag NPs@HA/DOX)之间的相互作用将DOX载入HA包覆的Ag NPs中。这些颗粒形态均匀,对正常细胞具有良好的生物相容性,并能在 pH 值敏感的条件下释放药物。值得注意的是,与游离 DOX 相比,Ag NPs@HA/DOX 由于 HA 与 CD44 受体表达过高的癌细胞之间的特异性相互作用,能显著提高抗肿瘤疗效,并能模拟三维球状模型。此外,Ag NPs@HA/DOX 对 HELA 异种移植小鼠模型的肿瘤抑制效果更佳,同时将游离 DOX 的全身毒性降至最低。根据以上结果,我们认为 Ag NPs@HA 有可能成为抗癌治疗中靶向递送各种治疗药物的纳米载体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
10.40
自引率
6.60%
发文量
639
审稿时长
29 days
期刊介绍: Journal of Industrial and Engineering Chemistry is published monthly in English by the Korean Society of Industrial and Engineering Chemistry. JIEC brings together multidisciplinary interests in one journal and is to disseminate information on all aspects of research and development in industrial and engineering chemistry. Contributions in the form of research articles, short communications, notes and reviews are considered for publication. The editors welcome original contributions that have not been and are not to be published elsewhere. Instruction to authors and a manuscript submissions form are printed at the end of each issue. Bulk reprints of individual articles can be ordered. This publication is partially supported by Korea Research Foundation and the Korean Federation of Science and Technology Societies.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信