Silver Ions Modified α-Fe2O3 Nanoparticles: An Efficient Antibacterial Agent for Multidrug Resistant Bacteria

IF 2.7 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Cluster Science Pub Date : 2024-08-08 DOI:10.1007/s10876-024-02680-3

Ritesh Verma, Satheesh Selvaraj, Ankush Chauhan, Rajasekaran Subbarayan, G. S. Hikku, Aaliya Ali, Preeti Thakur, Atul Thakur

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Abstract

Herein, silver ions modified α-Fe₂O₃ (Ag: α-Fe₂O₃) nanoparticles were synthesized using a sol-gel auto-combustion method comprising of dual phase i.e. trigonal structure of α-Fe₂O₃ and FCC structure of Ag. The refinement results verified the existence of both the phase with R-3c: R s and Fm-3 m space group. Transmission Electron Microscopy (TEM) showed the crystallite size around 34.24 ± 2.00 nm. The percentage of Ag⁰ and Ag⁺ verified through X-ray Photoelectron Spectroscopy (XPS) clearly indicate that around 74% of the Ag present is in the metallic form. The cyclic voltammetry showed that the C_sp of the Ag: α-Fe₂O₃ NPs modified electrode is 132 Fg ^− 1 and 100 Fg ^− 1 when recorded at a scan rate of 50 mVs^− 1 and 75 mVs^− 1, respectively. The Zones of Inhibition (ZOI) against bacterial strains generated by utilizing Ag: α-Fe₂O₃ NPs are clearly showed the ZOI of 19 ± 1 mm against Bacillus subtilis. The synthesized nanoparticles exhibited higher inhibition against the bacterial strains in comparison to the standard antibiotic ampicillin. Further, cell viability analysis suggested to use a concentration of 9 to 12 µg/ml for Ag: α-Fe₂O₃in invitro experiments.

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银离子修饰的 α-Fe2O3 纳米粒子：针对耐多药细菌的高效抗菌剂

本文采用溶胶-凝胶自动燃烧法合成了银离子修饰的α-Fe2O3（Ag: α-Fe2O3）纳米粒子，该纳米粒子具有双相结构，即α-Fe2O3的三叉结构和Ag的FCC结构。细化结果验证了 R-3c：R s 和 Fm-3 m 空间群相。透射电子显微镜（TEM）显示结晶尺寸约为 34.24 ± 2.00 nm。通过 X 射线光电子能谱（XPS）验证的 Ag0 和 Ag+ 的百分比清楚地表明，约 74% 的 Ag 以金属形式存在。循环伏安法显示，在扫描速率为 50 mVs- 1 和 75 mVs- 1 时，Ag：α-Fe2O3 NPs 修饰电极的 Csp 分别为 132 Fg - 1 和 100 Fg - 1。利用 Ag: α-Fe2O3 NPs 生成的细菌抑制区（ZOI）清楚地显示，对枯草杆菌的抑制区为 19 ± 1 mm。与标准抗生素氨苄西林相比，合成的纳米粒子对细菌菌株的抑制率更高。此外，细胞活力分析表明，在体外实验中，Ag: α-Fe2O3 的浓度应为 9 至 12 µg/ml。

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来源期刊

Journal of Cluster Science 化学-无机化学与核化学

CiteScore

6.70

自引率

0.00%

发文量

166

审稿时长

3 months

期刊介绍： The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.