The emergence and impact of the M1UK lineage on invasive Group A Streptococcus disease in Aotearoa New Zealand

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2024-08-09 DOI:10.1093/ofid/ofae457

Anna Vesty, Xiaoyun Ren, Prachi Sharma, Natalie Lorenz, T. Proft, Allan Hardaker, Christina Straub, J. Morgan, Audrey Tiong, Anneka Anderson, Rachel H Webb, Julie Bennett, Philip E Carter, N. Moreland

引用次数: 0

Abstract

M1UK is associated with current surges in invasive infection globally, partly due to increased production of superantigen SpeA. We show M1UK is now the dominant invasive emm1 lineage in New Zealand and is genomically related to community infections, suggesting measures that effectively prevent GAS-pharyngitis in children could reduce invasive disease.

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M1UK 菌系的出现及其对新西兰奥特亚罗瓦地区侵袭性 A 群链球菌疾病的影响

M1UK 与当前全球侵袭性感染激增有关，部分原因是超级抗原 SpeA 的产生增加。我们的研究表明，M1UK 现在是新西兰主要的侵袭性 emm1 株系，并且在基因组学上与社区感染有关，这表明有效预防儿童 GAS-咽炎的措施可以减少侵袭性疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.