Bokai Zhu, Silvia Liu, Natalie L. David, William Dion, Nandini K. Doshi, Lauren B. Siegel, Tânia Amorim, Rosemary E. Andrews, G. V. Naveen Kumar, Hanwen Li, Saad Irfan, Tristan Pesaresi, Ankit X. Sharma, Michelle Sun, Pouneh K. Fazeli, Matthew L. Steinhauser
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引用次数: 0
Abstract
Mice and many marine organisms exhibit ~12-h ultradian rhythms, however, direct evidence of ~12-h ultradian rhythms in humans is lacking. Here, we performed prospective, temporal transcriptome profiling of peripheral white blood cells from three healthy humans. All three participants independently exhibited robust ~12-h transcriptional rhythms in molecular programs involved in RNA and protein metabolism, with strong homology to circatidal gene programs previously identified in Cnidarian marine species.
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