A nuclear jamming transition in vertebrate organogenesis

IF 37.2 1区材料科学 Q1 CHEMISTRY, PHYSICAL

Nature Materials Pub Date : 2024-08-12 DOI:10.1038/s41563-024-01972-3

Sangwoo Kim, Rana Amini, Shuo-Ting Yen, Petr Pospíšil, Arthur Boutillon, Ilker Ali Deniz, Otger Campàs

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引用次数: 0

Abstract

Jamming of cell collectives and associated rigidity transitions have been shown to play a key role in tissue dynamics, structure and morphogenesis. Cellular jamming is controlled by cellular density and the mechanics of cell–cell contacts. However, the contribution of subcellular organelles to the physical state of the emergent tissue is unclear. Here we report a nuclear jamming transition in zebrafish retina and brain tissues, where physical interactions between highly packed nuclei restrict cellular movements and control tissue mechanics and architecture. Computational modelling suggests that the nuclear volume fraction and anisotropy of cells control the emerging tissue physical state. Analysis of tissue architecture, mechanics and nuclear movements during eye development show that retina tissues undergo a nuclear jamming transition as they form, with increasing nuclear packing leading to more ordered cellular arrangements, reminiscent of the crystalline cellular packings in the functional adult eye. Our results reveal an important role of the cell nucleus in tissue mechanics and architecture. Developing zebrafish retina and brain tissues undergo a nuclear jamming transition that induces crystalline-like cellular ordering, with the emergent tissue stiffness controlled by nuclear mechanics.

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脊椎动物器官形成过程中的核干扰转变

细胞集群的干扰和相关的刚度转换已被证明在组织动力学、结构和形态发生中起着关键作用。细胞干扰受细胞密度和细胞-细胞接触力学的控制。然而，亚细胞器对新生组织物理状态的贡献尚不清楚。在这里，我们报告了斑马鱼视网膜和脑组织中的核干扰转变，高度密集的细胞核之间的物理相互作用限制了细胞运动，并控制着组织的力学和结构。计算模型表明，细胞核体积分数和各向异性控制着新出现的组织物理状态。对眼球发育过程中的组织结构、力学和细胞核运动的分析表明，视网膜组织在形成过程中经历了细胞核堵塞的转变，细胞核堆积的增加导致细胞排列更加有序，这让人联想到功能性成眼中的晶体细胞堆积。我们的研究结果揭示了细胞核在组织力学和结构中的重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Materials 工程技术-材料科学：综合

CiteScore

62.20

自引率

0.70%

发文量

221

审稿时长

3.2 months

期刊介绍： Nature Materials is a monthly multi-disciplinary journal aimed at bringing together cutting-edge research across the entire spectrum of materials science and engineering. It covers all applied and fundamental aspects of the synthesis/processing, structure/composition, properties, and performance of materials. The journal recognizes that materials research has an increasing impact on classical disciplines such as physics, chemistry, and biology. Additionally, Nature Materials provides a forum for the development of a common identity among materials scientists and encourages interdisciplinary collaboration. It takes an integrated and balanced approach to all areas of materials research, fostering the exchange of ideas between scientists involved in different disciplines. Nature Materials is an invaluable resource for scientists in academia and industry who are active in discovering and developing materials and materials-related concepts. It offers engaging and informative papers of exceptional significance and quality, with the aim of influencing the development of society in the future.