Mononuclear cell phagocytosis in giant cell lesions of the jaws.

Stomatologija Pub Date : 2023-01-01
Sebastião Silvério Sousa-Neto, Gimenna Barbosa Pereira, Elismauro Francisco Mendonça, Allisson Filipe Lopes Martins
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Abstract

Background and objective: The central giant cell lesion (CGCL) is a benign intraosseous lesion that may resemble other giant cell-rich lesions, such as the peripheral giant cell lesion (PGCL). This lesion may be classified as aggressive or non-aggressive according to clinical and radiographic criteria, however, there is no biological marker that may help to define the CGCL based on the biological behavior. In this context, stromal cell phagocytosis has been described as an event related to aggressive lesions, however, only a few studies have investigated this phenomenon in CGCL. The aim of this study was to compare mononuclear cell phagocytosis by the multinucleated giant cells between aggressive, non-aggressive CGCL and PGCL.

Material and methods: Thirty-three cases of CGCL, 10 aggressive and 23 non-aggressive, and 20 cases of PGCL were included in this study. Phagocytosis events were evaluated in five consecutive microscopic fields from histological sections, stained with hematoxylin and eosin. The ratio between the numbers of phagocytosis/mm2and the total number of multinucleated giant cells/mm2was calculated.

Results: Phagocytosis was observed in the multinucleated giant cells of all cases. The density of phagocytosis/mm2in relation to giant cells/mm2was higher in the CGCL than in the PGCL. In addition, aggressive CGCL showed higher phagocytosis events when compared to the non-aggressive variant.

Conclusion: Our results suggest that the aggressiveness of multinucleated giant cell lesions of the jaws may be related to the number of phagocytosis events in the lesion.

颌骨巨细胞病变中的单核细胞吞噬作用。
背景和目的:中央巨细胞病变(CGCL)是一种良性骨内病变,可能类似于其他富含巨细胞的病变,如周围巨细胞病变(PGCL)。根据临床和放射学标准,这种病变可分为侵袭性和非侵袭性两种,但目前还没有生物标记物可以帮助根据生物行为来界定 CGCL。在这种情况下,基质细胞吞噬被描述为与侵袭性病变相关的事件,然而,只有少数研究对 CGCL 中的这一现象进行了调查。本研究旨在比较侵袭性、非侵袭性 CGCL 和 PGCL 多核巨细胞吞噬单核细胞的情况:本研究共纳入 33 例 CGCL(10 例侵袭性和 23 例非侵袭性)和 20 例 PGCL。用苏木精和伊红染色的组织学切片在五个连续的显微视野中对吞噬事件进行评估。计算吞噬数量/mm2与多核巨细胞总数/mm2之间的比率:结果:在所有病例的多核巨细胞中均观察到吞噬细胞。CGCL的吞噬密度/mm2与巨细胞/mm2的关系高于PGCL。此外,与非侵袭性变异型相比,侵袭性 CGCL 表现出更高的吞噬事件:我们的研究结果表明,颌骨多核巨细胞病变的侵袭性可能与病变中吞噬事件的数量有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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