Acute phase response and oxidative stress in coccidiosis: A review in domestic animals

IF 2 2区农林科学 Q2 PARASITOLOGY

Veterinary parasitology Pub Date : 2024-08-10 DOI:10.1016/j.vetpar.2024.110286

Seyed Mostafa Razavi , Mohammad Sajjad Soltan , Kiarash Abbasian , Ali Karami , Saeed Nazifi

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引用次数: 0

Abstract

Coccidiosis is a highly significant disease in domestic animals due to its global distribution and economic impact. The occurrence of oxidative stress (OS) and the acute phase response (APR) play crucial roles in the development of coccidiosis, thereby contributing to the pathogenicity of coccidia. A range of triggers including parasitic infection, can induce the APR. This response encompasses a set of hormonal and metabolic changes to restore body stability and improve the body's healing capabilities. Ovine coccidiosis has the potential to cause OS, which can be prevented and treated through the use of dietary additives. By including Curcuma longa in the diets of infected sheep, it is possible to reduce lipid peroxidation (LPO) and nitric oxide (NO) production, while simultaneously improving serum antioxidant capacity and interleukin-10 (IL-10) levels. Caprine coccidiosis can activate the APR. Research indicated that goats suffering from coccidiosis exhibited elevated concentrations of malondialdehyde (MDA) and total homocysteine, along with reduced levels of some enzymes such as superoxide dismutase (SOD) and glutathione reductase (GR), as well as decreased levels of zinc (Zn), manganese (Mn), selenium (Se), vitamin C, and total antioxidant capacity (TAC). Bovine coccidiosis is linked to elevated MDA concentrations and reduced serum glutathione (GSH) and TAC levels. Eimeria can induce OS and inflammatory damage in infected birds by releasing pro-inflammatory mediators from cells, resulting in a significant increase in CAT and SOD activity, lipid peroxidation and damage to the intestinal epithelium. To promote the antioxidant system of infected birds, some herbal food additives such as grape seed proanthocyanidine extract, Curcuma longa and Rumex nervosus leaf extract, can be used. Research on the APR in birds is not as extensive as in ruminants. Currently, there is a lack of studies on the occurrence of OS and APR in camels, horses, dogs, and cats with coccidiosis.

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球虫病的急性期反应和氧化应激：家畜中的急性期反应和氧化应激：综述。

由于球虫病在全球的分布和经济影响，它在家畜中是一种非常重要的疾病。氧化应激（OS）和急性期反应（APR）的发生在球虫病的发展过程中起着至关重要的作用，从而导致球虫的致病性。包括寄生虫感染在内的一系列诱因都会诱发急性期反应。这种反应包括一系列激素和新陈代谢的变化，以恢复机体的稳定性并提高机体的愈合能力。绵羊球虫病有可能导致OS，可以通过使用膳食添加剂来预防和治疗。在受感染绵羊的日粮中添加姜黄，可以减少脂质过氧化（LPO）和一氧化氮（NO）的产生，同时提高血清抗氧化能力和白细胞介素-10（IL-10）水平。山羊球虫病可激活 APR。研究表明，患有球虫病的山羊体内丙二醛（MDA）和总同型半胱氨酸的浓度升高，超氧化物歧化酶（SOD）和谷胱甘肽还原酶（GR）等酶的水平降低，锌（Zn）、锰（Mn）、硒（Se）、维生素 C 和总抗氧化能力（TAC）的水平下降。牛球虫病与 MDA 浓度升高、血清谷胱甘肽（GSH）和 TAC 水平降低有关。艾美耳菌可通过释放细胞中的促炎介质，诱发受感染禽类的OS和炎症损伤，导致CAT和SOD活性显著增加、脂质过氧化和肠上皮损伤。为促进受感染禽类的抗氧化系统，可使用一些草药食品添加剂，如葡萄籽原花青素提取物、莪术和牛肝菌叶提取物。有关禽类 APR 的研究不如反刍动物广泛。目前，还缺乏对患有球虫病的骆驼、马、狗和猫发生 OS 和 APR 的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary parasitology 农林科学-寄生虫学

CiteScore

5.30

自引率

7.70%

发文量

126

审稿时长

36 days

期刊介绍： The journal Veterinary Parasitology has an open access mirror journal,Veterinary Parasitology: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. This journal is concerned with those aspects of helminthology, protozoology and entomology which are of interest to animal health investigators, veterinary practitioners and others with a special interest in parasitology. Papers of the highest quality dealing with all aspects of disease prevention, pathology, treatment, epidemiology, and control of parasites in all domesticated animals, fall within the scope of the journal. Papers of geographically limited (local) interest which are not of interest to an international audience will not be accepted. Authors who submit papers based on local data will need to indicate why their paper is relevant to a broader readership. Parasitological studies on laboratory animals fall within the scope of the journal only if they provide a reasonably close model of a disease of domestic animals. Additionally the journal will consider papers relating to wildlife species where they may act as disease reservoirs to domestic animals, or as a zoonotic reservoir. Case studies considered to be unique or of specific interest to the journal, will also be considered on occasions at the Editors'' discretion. Papers dealing exclusively with the taxonomy of parasites do not fall within the scope of the journal.