Therapeutic Advances in Obesity: How Real-World Evidence Impacts Affordability Beyond Standard of Care.

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL
Pragmatic and Observational Research Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI:10.2147/POR.S471476
Dimitrios Patoulias, Theocharis Koufakis, Ieva Ruža, Mohamed El-Tanani, Manfredi Rizzo
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Abstract

Obesity is currently considered a global epidemic, with rising prevalence worldwide and rather pessimistic projections. Based on its close interconnection with various co-morbidities, such as diabetes mellitus and cardiovascular disease, obesity is associated with significant increases in morbidity and mortality, while it also poses a substantial economic burden for national healthcare systems. Apparently, the majority of individuals classified as obese do not achieve adequate weight loss with the adoption of a healthy lifestyle intervention, including dietary modification and physical activity. Fortunately, during the last decade, a significant progress in pharmacotherapy of obesity has been observed, with the introduction of agents that have gained approval from regulatory authorities, namely semaglutide, liraglutide and tirzepatide, due to their impressive results in body weight reduction, alongside their beneficial, pleiotropic effects. The aim of the present review article is to discuss on evidence retrieved from real-world studies regarding the efficacy of those agents in obesity treatment, with emphasis on cost-effectiveness data, towards an effort to tackle efficiently the progression of obesity epidemic.

肥胖症的治疗进展:现实世界的证据如何影响超出标准治疗的可负担性。
肥胖症目前被认为是一种全球性流行病,在全世界的发病率不断上升,但预测结果却相当悲观。肥胖症与糖尿病和心血管疾病等多种并发症密切相关,导致发病率和死亡率大幅上升,同时也给国家医疗保健系统带来了沉重的经济负担。显然,大多数被归类为肥胖症的人在采取健康生活方式干预措施(包括饮食调整和体育锻炼)后,体重并没有得到充分减轻。幸运的是,在过去的十年中,肥胖症的药物治疗取得了重大进展,一些药物获得了监管机构的批准,如塞马鲁肽、利拉鲁肽和替泽帕肽,这些药物在减轻体重方面效果显著,同时还具有有益的多生物效应。本综述文章旨在讨论从实际研究中获取的有关这些药物治疗肥胖症疗效的证据,重点是成本效益数据,以努力有效地应对肥胖症流行病的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pragmatic and Observational Research
Pragmatic and Observational Research MEDICINE, GENERAL & INTERNAL-
自引率
0.00%
发文量
11
期刊介绍: Pragmatic and Observational Research is an international, peer-reviewed, open-access journal that publishes data from studies designed to closely reflect medical interventions in real-world clinical practice, providing insights beyond classical randomized controlled trials (RCTs). While RCTs maximize internal validity for cause-and-effect relationships, they often represent only specific patient groups. This journal aims to complement such studies by providing data that better mirrors real-world patients and the usage of medicines, thus informing guidelines and enhancing the applicability of research findings across diverse patient populations encountered in everyday clinical practice.
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