Association between temperatures and type 2 diabetes: A prospective study in UK Biobank

IF 6.1 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM
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引用次数: 0

Abstract

Objective

This study aims to prospectively examine the association between temperatures and the occurrence of type 2 diabetes (T2D).

Methods

We used the CPH models to analyze 103,215 non-diabetic participants in the UK Biobank cohort who answered questions about workplace temperature, to evaluate the survival relationship, and the interaction effects of working environmental temperature and T2D-related genetic risk scores (GRS) on the occurrence of T2D. The occurrence of T2D was assessed by hospital inpatient records. The weighted T2D-related GRS were calculated.

Results

During 1,355,200.6 person-years follow-up, a total of 2436 participants were documented as having diagnosed T2D. After adjustment, compared to the comfortable group, the participants working in non-comfortable environmental temperature had greater risk of T2D (HR: 1.27, 95 %CI: 1.04 to 1.55, for cold; HR: 1.32, 95 %CI: 1.17 to 1.48 for hot; HR: 1.51, 95 %CI: 1.38 to 1.65 for alternate). Similarly, individuals exposed to different levels of genetic risk scores in alternating hot and cold work environments had a higher risk of developing type 2 diabetes.

Conclusions

This study found working in single non-comfortable environmental temperatures was associated with greater risk of T2D occurrence, and exposure to alternating environmental temperatures had the highest risk of range and severity.

Abstract Image

气温与 2 型糖尿病之间的关系:英国生物数据库前瞻性研究。
研究目的本研究旨在对温度与2型糖尿病(T2D)发生之间的关系进行前瞻性研究:我们使用CPH模型分析了英国生物库队列中103215名回答了有关工作场所温度问题的非糖尿病参与者,以评估工作环境温度与T2D相关遗传风险评分(GRS)对T2D发生的生存关系和交互效应。T2D的发生率通过医院住院病历进行评估。计算了与 T2D 相关的加权遗传风险评分:结果:在 1355200.6 人年的随访中,共有 2436 名参与者确诊为 T2D。经调整后,与舒适环境组相比,在不舒适环境温度下工作的参与者患 T2D 的风险更高(寒冷环境组 HR:1.27,95%CI:1.04 至 1.55;炎热环境组 HR:1.32,95%CI:1.17 至 1.48;交替环境组 HR:1.51,95%CI:1.38 至 1.65)。同样,在冷热交替的工作环境中暴露于不同程度遗传风险分数的人患 2 型糖尿病的风险更高:本研究发现,在单一的非舒适环境温度下工作与发生 T2D 的更大风险相关,而暴露于交替环境温度下的风险范围和严重程度最高。
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来源期刊
Diabetes research and clinical practice
Diabetes research and clinical practice 医学-内分泌学与代谢
CiteScore
10.30
自引率
3.90%
发文量
862
审稿时长
32 days
期刊介绍: Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.
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