Treatment of Refractory Segmental Vitiligo and Alopecia Areata in a Child with Upadacitinib and NB-UVB: A Case Report.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S467026

Yuzhu Mu, Ting Pan, Lingling Chen

引用次数: 0

Abstract

Vitiligo and alopecia areata are both autoimmune skin diseases, and the chances of co-occurrence are very low. Conventional treatments often include glucocorticoids, which have many adverse reactions with long-term use and are difficult to achieve satisfactory results. Upadacitinib has been found to be effective in both vitiligo and alopecia areata due to partial overlap in pathogenic pathways. We report the successful treatment of vitiligo combined with alopecia areata in a nine-year-old child with upadacitinib in combination with UVB. The area of vitiligo and alopecia areata decreased significantly, and satisfactory results were obtained. It provides a new idea for the treatment of vitiligo complicated with alopecia areata in children.

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用乌达帕替尼和 NB-UVB 治疗儿童难治性节段型白癜风和斑秃：病例报告。

白癜风和斑秃都是自身免疫性皮肤病，同时发病的几率非常低。传统的治疗方法通常包括糖皮质激素，但长期使用糖皮质激素会产生许多不良反应，而且很难达到满意的效果。由于致病途径部分重叠，乌达替尼对白癜风和斑秃均有疗效。我们报告了乌达替尼联合紫外线成功治疗一名九岁儿童白癜风合并斑秃的病例。白癜风和斑秃的面积明显缩小，取得了令人满意的疗效。这为治疗儿童白癜风合并斑秃提供了一个新思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.