Health Risk Assessment of Toxic Metal(loids) Consumed Through Plant-Based Anti-diabetic Therapeutics Collected in the Northern Divisional City of Rajshahi, Bangladesh.

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biological Trace Element Research Pub Date : 2025-04-01 Epub Date: 2024-08-12 DOI:10.1007/s12011-024-04338-7
Nazmul Islam, Rausan Zamir, Omar Faruque
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Abstract

The present study investigates human health risks upon consumption of herbal medicines in terms of ten toxic metalloids in 20 plant-based anti-diabetic therapeutics. The analysis of metalloids was determined by an atomic absorption spectrometer after microwave-assisted digestion. The computation of hazard quotients (HQ) and hazard indexes (HI) of metalloids leads to the assessment of non-carcinogenic health risks. Carcinogenic risk was assessed based on cancer slope factor (CSF) and chronic daily intake (CDI) values. Comparison with WHO regulatory cut-off points for each metalloid: seven samples for Mn, 12 samples for Hg, three samples for Cu, eight samples for Ni, four samples for Cd, two samples for Pb, one sample for Cr, and eight samples for Zn are unsafe to consume. Non-carcinogenic human health risk is predicted for Mn in seven samples, Fe in one sample, Hg in ten samples, Cu in three samples, Ni in one sample, and Pb in two samples. HI values greater than 1 predict non-carcinogenic health risk in thirteen samples. Incremental lifetime cancer risk (ILCR) remains for As (inorganic) in 12 samples, Cr (+ 6) in one sample, and Pb in no samples. To guarantee consumer safety, the implementation of strict monitoring is suggested.

孟加拉国拉杰沙希北部分区城市采集的植物性抗糖尿病药物中有毒金属(loids)的健康风险评估。
本研究从 20 种基于植物的抗糖尿病治疗药物中的 10 种有毒金属物质入手,调查了食用中草药对人体健康的危害。在微波辅助消解后,使用原子吸收光谱仪对金属物质进行了分析。通过计算类金属的危害商(HQ)和危害指数(HI),可以评估非致癌健康风险。致癌风险根据癌症斜率因子 (CSF) 和慢性每日摄入量 (CDI) 值进行评估。与世界卫生组织规定的每种类金属的临界值相比:锰有 7 个样本、汞有 12 个样本、铜有 3 个样本、镍有 8 个样本、镉有 4 个样本、铅有 2 个样本、铬有 1 个样本、锌有 8 个样本不能安全食用。据预测,7 个样本中的锰、1 个样本中的铁、10 个样本中的汞、3 个样本中的铜、1 个样本中的镍、2 个样本中的铅对人体健康有非致癌风险。HI 值大于 1 的 13 个样本中,预测存在非致癌健康风险。12 个样本中的砷(无机物)、1 个样本中的铬(+ 6)和 2 个样本中的铅仍然存在终生致癌风险(ILCR)。为了保证消费者的安全,建议实施严格的监测。
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来源期刊
Biological Trace Element Research
Biological Trace Element Research 生物-内分泌学与代谢
CiteScore
8.70
自引率
10.30%
发文量
459
审稿时长
2 months
期刊介绍: Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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