Ya Huang, Kuanming Yao, Qiang Zhang, Xingcan Huang, Zhenlin Chen, Yu Zhou and Xinge Yu
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引用次数: 0
Abstract
Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat a broad spectrum of health conditions. Electrical stimulation (ES) is a pivotal technique in bioelectronics, offering a precise, non-pharmacological means to modulate and control biological processes across molecular, cellular, tissue, and organ levels. This method holds the potential to restore or enhance physiological functions compromised by diseases or injuries by integrating sophisticated electrical signals, device interfaces, and designs tailored to specific biological mechanisms. This review explains the mechanisms by which ES influences cellular behaviors, introduces the essential stimulation principles, discusses the performance requirements for optimal ES systems, and highlights the representative applications. From this review, we can realize the potential of ES based bioelectronics in therapy, regenerative medicine and rehabilitation engineering technologies, ranging from tissue engineering to neurological technologies, and the modulation of cardiovascular and cognitive functions. This review underscores the versatility of ES in various biomedical contexts and emphasizes the need to adapt to complex biological and clinical landscapes it addresses.
生物电子学是一个热门的研究课题,也是一种重要的工具,因为它有助于制造与生物系统相互作用的先进医疗设备,从而有效地诊断、监测和治疗各种健康问题。电刺激(ES)是生物电子学的一项关键技术,它提供了一种精确的、非药物的方法,可以调节和控制分子、细胞、组织和器官层面的生物过程。这种方法通过整合复杂的电信号、设备接口和针对特定生物机制的设计,有望恢复或增强因疾病或损伤而受损的生理功能。本综述解释了 ES 影响细胞行为的机制,介绍了基本的刺激原理,讨论了最佳 ES 系统的性能要求,并重点介绍了具有代表性的应用。从这篇综述中,我们可以认识到基于 ES 的生物电子学在治疗、再生医学和康复工程技术方面的潜力,包括组织工程到神经技术,以及心血管和认知功能的调节。这篇综述强调了 ES 在各种生物医学环境中的多功能性,并强调了适应其所涉及的复杂生物和临床环境的必要性。
期刊介绍:
Chemical Society Reviews is published by: Royal Society of Chemistry.
Focus: Review articles on topics of current interest in chemistry;
Predecessors: Quarterly Reviews, Chemical Society (1947–1971);
Current title: Since 1971;
Impact factor: 60.615 (2021);
Themed issues: Occasional themed issues on new and emerging areas of research in the chemical sciences