Particulate matter-induced oxidative stress – Mechanistic insights and antioxidant approaches reported in in vitro studies

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-08-09 DOI:10.1016/j.etap.2024.104529

Vânia Vilas-Boas, Nivedita Chatterjee, Andreia Carvalho, Ernesto Alfaro-Moreno

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引用次数: 0

Abstract

Inhaled particulate matter (PM) is a key factor in millions of yearly air pollution-related deaths worldwide. The oxidative potential of PM indicates its ability to promote an oxidative environment. Excessive reactive oxygen species (ROS) can cause cell damage via oxidative stress, leading to inflammation, endoplasmic reticulum stress, airway remodeling, and various cell death modes (apoptosis, ferroptosis, pyroptosis). ROS can also interact with macromolecules, inducing DNA damage and epigenetic modifications, disrupting homeostasis. These effects have been studied extensively in vitro and confirmed in vivo.

This review explores the oxidative potential of airborne particles and PM-induced ROS-mediated cellular damage observed in vitro, highlighting the link between oxidative stress, inflammation, and cell death modes described in the latest literature. The review also analyzes the effects of ROS on DNA damage, repair, carcinogenicity, and epigenetics. Additionally, the latest developments on the potential of antioxidants to prevent ROS’s harmful effects are described, providing future perspectives on the topic.

查看原文本刊更多论文

颗粒物质诱发的氧化应激--体外研究中报告的机理认识和抗氧化方法。

全世界每年有数百万人因空气污染而死亡，吸入的颗粒物（PM）是其中的一个关键因素。可吸入颗粒物的氧化潜能表明它能够促进氧化环境。过量的活性氧（ROS）可通过氧化应激造成细胞损伤，导致炎症、内质网应激、气道重塑和各种细胞死亡模式（凋亡、铁跃变、热跃变）。ROS 还能与大分子相互作用，诱发 DNA 损伤和表观遗传修饰，从而破坏体内平衡。这些影响已在体外得到广泛研究，并在体内得到证实。本综述探讨了空气传播颗粒的氧化潜能和体外观察到的 PM 诱导的 ROS 介导的细胞损伤，强调了最新文献中描述的氧化应激、炎症和细胞死亡模式之间的联系。综述还分析了 ROS 对 DNA 损伤、修复、致癌性和表观遗传学的影响。此外，还介绍了抗氧化剂在防止 ROS 有害影响方面的最新进展，为这一主题提供了未来展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.