Storage, preservation, and rehabilitation of living heart valves to treat congenital heart disease.

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2024-08-09 DOI:10.1016/j.medj.2024.07.004

Elizabeth M Cordoves, Giovanni Ferrari, Emmanuel Zorn, Emile Bacha, Gordana Vunjak-Novakovic, David M Kalfa

引用次数: 0

Abstract

Heart valve disease patients undergo multiple surgeries to replace structurally degraded valve prostheses, highlighting the need for valve replacements with growth and self-repair capacity. Given allogeneic valve transplantation's promise in meeting these goals by delivering a living valve replacement, we propose a framework for preserving and rehabilitating living valves ex vivo.

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储存、保存和康复活体心脏瓣膜，以治疗先天性心脏病。

心脏瓣膜病患者需要接受多次手术来更换结构退化的瓣膜假体，这凸显了对具有生长和自我修复能力的瓣膜替代物的需求。鉴于同种异体瓣膜移植有望通过提供活体瓣膜替代物来实现这些目标，我们提出了一个在体外保存和修复活体瓣膜的框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.