Glucagon-like peptide receptor-1 receptor agonists: The emerging fourth pillar in type 2 diabetes and chronic kidney disease?

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2024-08-09 DOI:10.1016/j.medj.2024.06.010

James Ling, Elaine Chow

引用次数: 0

Abstract

Previously, no randomized controlled trials investigated the renoprotective effects of glucagon-like peptide-1 receptor agonists (GLP-1RA) as the primary endpoint in patients with diabetes and chronic kidney disease. In the FLOW trial, Perkovic et al. showed that once-weekly semaglutide reduced kidney failure, kidney-related death, and cardiovascular death by 24% as compared with placebo in patients with type 2 diabetes at high risk of renal progression.¹.

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胰高血糖素样肽受体-1 受体激动剂：2 型糖尿病和慢性肾脏病的新兴第四支柱？

此前，没有随机对照试验将胰高血糖素样肽-1 受体激动剂（GLP-1RA）的肾保护作用作为糖尿病和慢性肾病患者的主要终点进行研究。在 FLOW 试验中，Perkovic 等人的研究表明，与安慰剂相比，每周服用一次的塞马鲁肽可将肾功能衰竭、肾脏相关死亡和心血管死亡的发生率降低 24%，而安慰剂则可将肾功能衰竭、肾脏相关死亡和心血管死亡的发生率降低 24%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

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