Asciminib: the next-generation bullet for first-line treatment of chronic myeloid leukemia.

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2024-08-09 DOI:10.1016/j.medj.2024.07.001

Chikashi Yoshida, Tomoiku Takaku

引用次数: 0

Abstract

The standard of care for chronic myeloid leukemia (CML) involves tyrosine kinase inhibitors (TKIs), which suppress tyrosine kinase activity of BCR::ABL1. Hochhaus et al. reported that asciminib, a BCR::ABL1 inhibitor specifically targeting the ABL myristoyl pocket, showed superior efficacy and favorable safety compared with TKIs in the phase 3 ASC4FIRST trial in patients with newly diagnosed chronic-phase CML.¹.

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Asciminib：用于慢性髓性白血病一线治疗的新一代子弹。

慢性髓性白血病（CML）的标准治疗方法是使用酪氨酸激酶抑制剂（TKIs），抑制 BCR::ABL1 的酪氨酸激酶活性。Hochhaus等人报告说，在ASC4FIRST三期试验中，一种特异性靶向ABL肉豆蔻酰口袋的BCR::ABL1抑制剂Asciminib在新诊断的慢性期CML患者中显示出优于TKIs的疗效和良好的安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

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