Evaluating the complement C1q levels in serum and cerebrospinal fluid in multiple sclerosis patients: Could it serve as a valuable marker in clinical practice?

IF 2.9 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2024-08-03 DOI:10.1016/j.jneuroim.2024.578428

Jordi Tortosa-Carreres , Laura Cubas-Núñez , Mónica Piqueras , Jéssica Castillo-Villalba , Carlos Quintanilla-Bordàs , Ana Quiroga-Varela , Noelia Villarrubia , Enric Monreal , Gary Álvarez , Raquel Gasque-Rubio , Lorena Forés-Toribio , Sara Carratalà-Boscà , Celia Lucas , María T. Sanz , Lluís Ramió-Torrentà , Luisa María Villar , Bonaventura Casanova , Begoña Laiz , Francisco Carlos Pérez-Miralles

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引用次数: 0

Abstract

Immunohistochemical studies have identified complement component C1q in MS lesions. We aimed to compare serum (sC1q) and CSF (csfC1q) levels in a large cohort of MS patients (pwMS) (n = 222) with those of healthy controls (HC, n = 52), individuals with other immune (IND, n = 14), and non-immune neurological disorders (nIND, n = 15), and to analyze their correlation with other biomarkers.

pwMS were divided into three series based on their origin. CSF samples were unavailable for HC. All three pwMS cohorts had lower sC1q levels compared to HC and IND. csfC1q was higher in one pwMS cohort, with a trend in another, and correlated with IgG, Free Kappa Light Chains, GFAP, and Chitinase-3 Like Protein-1 in CSF. Our findings suggest a significant role for C1q in MS pathophysiology, potentially serving as a biomarker for disease identification.

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评估多发性硬化症患者血清和脑脊液中的补体 C1q 水平：它能作为临床实践中的重要标记物吗？

免疫组化研究发现多发性硬化症病变中存在补体成分 C1q。我们的目的是比较一大群多发性硬化症患者（pwMS，n = 222）与健康对照组（HC，n = 52）、其他免疫性疾病患者（IND，n = 14）和非免疫性神经系统疾病患者（nIND，n = 15）的血清（sC1q）和脑脊液（csfC1q）水平，并分析它们与其他生物标志物的相关性。HC无法获得CSF样本。与 HC 和 IND 相比，所有三个 pwMS 组群的 sC1q 水平都较低。一个 pwMS 组群的 csfC1q 水平较高，另一个呈上升趋势，并与 CSF 中的 IgG、游离 Kappa 轻链、GFAP 和几丁质酶-3 类蛋白-1 相关。我们的研究结果表明，C1q在多发性硬化症的病理生理学中起着重要作用，有可能成为疾病识别的生物标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.