A brief history and future directions of dielectrophoretic filtration: A review.

IF 3 3区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

ELECTROPHORESIS Pub Date : 2024-08-09 DOI:10.1002/elps.202400116

Mary Clare O'Donnell, Mariia Kepper, Georg R Pesch

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Abstract

Dielectrophoresis (DEP) is an electrokinetic effect first studied in the early 20th century. Since then, DEP has gained significant interest in research, owing to its ability to solve particle separation problems in various industries. Dielectrophoretic filtration (DEP filtration) is a separation method using DEP to filter a wide range of microparticles, from bacterial cells to catalytic particles. DEP filtration can selectively separate particles based on size or dielectric properties, recover trapped particles and avoid common problems associated with mechanical filtration based on pore size (e.g. pressure drops and regular filter replacements). This review describes the simple beginnings of DEP filtration and how our understanding and applications for DEP filtration have progressed over time. A brief section of DEP theory as well as a note on the general outlook for DEP filtration in the future is presented. DEP filtration offers an exciting opportunity to selectively separate diverse particle mixtures. To achieve such a feat, technical challenges such as Joule Heating and low throughputs must be addressed.

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介质电泳过滤的简史和未来方向：综述。

Dielectrophoresis (DEP) 是 20 世纪初首次研究的一种电动效应。从那时起，由于 DEP 能够解决各行各业的颗粒分离问题，因此在研究中获得了极大的关注。压电过滤（DEP 过滤）是一种利用 DEP 过滤各种微粒（从细菌细胞到催化微粒）的分离方法。DEP 过滤可根据颗粒的大小或介电性质选择性地分离颗粒，回收被截留的颗粒，并避免与基于孔径的机械过滤相关的常见问题（如压力下降和定期更换过滤器）。本综述介绍了 DEP 过滤的简单起源，以及我们对 DEP 过滤的理解和应用是如何随着时间的推移而不断进步的。文中简要介绍了 DEP 理论，并对 DEP 过滤的未来进行了总体展望。DEP 过滤为选择性分离各种颗粒混合物提供了一个令人兴奋的机会。要实现这一壮举，必须解决焦耳热和低吞吐量等技术难题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ELECTROPHORESIS 生物-分析化学

CiteScore

6.30

自引率

13.80%

发文量

244

审稿时长

1.9 months

期刊介绍： ELECTROPHORESIS is an international journal that publishes original manuscripts on all aspects of electrophoresis, and liquid phase separations (e.g., HPLC, micro- and nano-LC, UHPLC, micro- and nano-fluidics, liquid-phase micro-extractions, etc.). Topics include new or improved analytical and preparative methods, sample preparation, development of theory, and innovative applications of electrophoretic and liquid phase separations methods in the study of nucleic acids, proteins, carbohydrates natural products, pharmaceuticals, food analysis, environmental species and other compounds of importance to the life sciences. Papers in the areas of microfluidics and proteomics, which are not limited to electrophoresis-based methods, will also be accepted for publication. Contributions focused on hyphenated and omics techniques are also of interest. Proteomics is within the scope, if related to its fundamentals and new technical approaches. Proteomics applications are only considered in particular cases. Papers describing the application of standard electrophoretic methods will not be considered. Papers on nanoanalysis intended for publication in ELECTROPHORESIS should focus on one or more of the following topics: • Nanoscale electrokinetics and phenomena related to electric double layer and/or confinement in nano-sized geometry • Single cell and subcellular analysis • Nanosensors and ultrasensitive detection aspects (e.g., involving quantum dots, "nanoelectrodes" or nanospray MS) • Nanoscale/nanopore DNA sequencing (next generation sequencing) • Micro- and nanoscale sample preparation • Nanoparticles and cells analyses by dielectrophoresis • Separation-based analysis using nanoparticles, nanotubes and nanowires.