Immunoglobulin G glycosylation and its alterations in aging-related diseases.

IF 3.3 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Acta biochimica et biophysica Sinica Pub Date : 2024-08-08 DOI:10.3724/abbs.2024137

Yongqi Wu, Zhida Zhang, Lin Chen, Shisheng Sun

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Abstract

Immunoglobulin G (IgG) is an important serum glycoprotein and a major component of antibodies. Glycans on IgG affect the binding of IgG to the Fc receptor or complement C1q, which in turn affects the biological activity and biological function of IgG. Altered glycosylation patterns on IgG emerge as important biomarkers in the aging process and age-related diseases. Key aging-related alterations observed in IgG glycosylation include reductions in galactosylation and sialylation, alongside increases in agalactosylation, and bisecting GlcNAc. Understanding the role of IgG glycosylation in aging-related diseases offers insights into disease mechanisms and provides opportunities for the development of diagnostic and therapeutic strategies. This review summarizes five aspects of IgG: an overview of IgG, IgG glycosylation, IgG glycosylation with inflammation mediation, IgG glycan changes with normal aging, as well as the relevance of IgG glycan changes to aging-related diseases. This review provides a reference for further investigation of the regulatory mechanisms of IgG glycosylation in aging-related diseases, as well as for evaluating the potential of IgG glycosylation changes as markers of aging and aging-related diseases.

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免疫球蛋白 G 糖基化及其在衰老相关疾病中的改变

免疫球蛋白 G（IgG）是一种重要的血清糖蛋白，也是抗体的主要成分。IgG 上的糖类会影响 IgG 与 Fc 受体或补体 C1q 的结合，进而影响 IgG 的生物活性和生物功能。IgG 上糖基化模式的改变成为衰老过程和老年相关疾病的重要生物标志物。在 IgG 糖基化中观察到的与衰老相关的主要改变包括半乳糖基化和糖基化的减少，以及半乳糖基化和 GlcNAc 分叉的增加。了解 IgG 糖基化在衰老相关疾病中的作用有助于深入了解疾病机制，并为开发诊断和治疗策略提供机会。本综述总结了IgG的五个方面：IgG概述、IgG糖基化、IgG糖基化与炎症介导、IgG糖基化变化与正常衰老，以及IgG糖基化变化与衰老相关疾病的关系。这篇综述为进一步研究 IgG 糖基化在衰老相关疾病中的调控机制以及评估 IgG 糖基化变化作为衰老和衰老相关疾病标志物的潜力提供了参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta biochimica et biophysica Sinica 生物-生化与分子生物学

CiteScore

5.00

自引率

5.40%

发文量

170

审稿时长

3 months

期刊介绍： Acta Biochimica et Biophysica Sinica (ABBS) is an internationally peer-reviewed journal sponsored by the Shanghai Institute of Biochemistry and Cell Biology (CAS). ABBS aims to publish original research articles and review articles in diverse fields of biochemical research including Protein Science, Nucleic Acids, Molecular Biology, Cell Biology, Biophysics, Immunology, and Signal Transduction, etc.