Primary intestinal T-cell and natural killer-cell lymphomas: Clinicopathologic and prognostic features of 79 cases in South China.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-08-09 DOI:10.1093/ajcp/aqae102

Na Guo, Chunlu Zhou, Yu Wang, Jia Fu, Yueqiong Chen, Fang Wang, Huilan Rao

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引用次数: 0

Abstract

Objectives: Primary intestinal T-cell and natural killer-cell lymphomas (PITNKLs) are aggressive and make pathologic diagnoses in biopsy specimens challenging. We analyzed different subtypes' clinicopathologic features and treatment outcomes.

Methods: Seventy-nine PITNKL cases were characterized by clinical, morphologic, and immunohistochemical features.

Results: Among 79 cases of PITNKLs from 2008 to 2017 in our institution, 40 (50.63%) were extranodal NK/T-cell lymphoma, nasal type (ENKTL); 32 (40.51%) monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL); 6 (7.59%) intestinal T-cell lymphoma, not otherwise specified; and 1 (1.27%) indolent T-cell lymphoma of the gastrointestinal tract. Small intestine (n = 47) was the most common site. Monomorphic epitheliotropic intestinal T-cell lymphoma showed distinctive clinicopathologic features from other subtypes with high expression (96.88%) of spleen tyrosine kinase (SYK) and PD-L1 (87.5%) and the poorest prognosis (P < .001). CD30 was highly expressed in ENKTL (9/17, 57.94%) and irrelevant to prognosis (P > .05).

Conclusions: Cases of PITNKL are biologically heterogeneous; most have a dismal prognosis. SYK and PD-L1 expression might be a significant marker for MEITL and helps differential diagnosis.

查看原文本刊更多论文

原发性肠T细胞和自然杀伤细胞淋巴瘤：华南地区79例病例的临床病理和预后特征。

目的：原发性肠T细胞和自然杀伤细胞淋巴瘤（PITNKLs）具有侵袭性，活检标本的病理诊断具有挑战性。我们分析了不同亚型的临床病理特征和治疗效果：方法：对79例PITNKL病例进行临床、形态学和免疫组化特征描述：在我院2008年至2017年的79例PITNKL病例中，40例（50.63%）为结节外NK/T细胞淋巴瘤，鼻型（ENKTL）；32例（40.51%）为单形上皮细胞性肠T细胞淋巴瘤（MEITL）；6例（7.59%）为肠T细胞淋巴瘤，未作其他说明；1例（1.27%）为胃肠道不显性T细胞淋巴瘤。小肠（47 例）是最常见的部位。单形上皮细胞性肠T细胞淋巴瘤显示出与其他亚型不同的临床病理特征，脾酪氨酸激酶（SYK）和PD-L1（87.5%）高表达（96.88%），预后最差（P < .001）。CD30在ENKTL中高表达（9/17，57.94%），与预后无关（P > .05）：结论：PITNKL病例具有生物异质性；大多数预后不良。SYK和PD-L1的表达可能是MEITL的重要标志物，有助于鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464