Predictors of distant metastatic recurrence in head and neck cutaneous squamous cell carcinoma with lymph node metastases treated with curative intent: A multicenter study.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Ardalan Ebrahimi, Ruta Gupta, Lachlan McDowell, Matthew J R Magarey, Paul N Smith, Klaus-Martin Schulte, Diana M Perriman, Michael Veness, Sandro Porceddu, Tsu-Hui Hubert Low, Allan Fowler, Jonathan R Clark
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Abstract

Background: We aimed to identify predictors of distant metastatic recurrence (DMR) in patients with head and neck cutaneous squamous cell carcinoma (HNcSCC) with nodal metastases treated with curative intent.

Methods: Predictors of DMR were identified using Cox regression in a multicenter study of 1151 patients.

Results: The 5-year risk of DMR was 9.6%. On multivariate analysis, immunosuppression (HR 2.93; 95% CI: 1.70-5.05; p < 0.001), nodal size >6 cm [versus ≤3 cm (HR 2.77; 95% CI: 1.09-7.03; p = 0.032)], ≥5 nodal metastases [versus 1-2 (HR 2.79; 95% CI: 1.63-4.78; p < 0.001)], and bilateral disease (HR 3.11; 95% CI: 1.40-6.90; p = 0.005) predicted DMR. A DMR risk score was developed that stratified risk from 6.6% (no risk factors) to 100% (≥3 risk factors) (p < 0.001).

Conclusions: The risk of DMR in nodal metastatic HNcSCC increases with immunosuppression, nodal size >6 cm, ≥5 nodal metastases, and bilateral disease. A simple DMR risk score estimated prior to treatment may be clinically useful.

头颈部皮肤鳞状细胞癌淋巴结转移治愈性远处转移复发的预测因素:一项多中心研究。
背景:我们旨在确定头颈部皮肤鳞状细胞癌(HNcSCC)患者远处转移性复发(DMR)的预测因素,这些患者均接受过治愈性治疗:在对1151名患者进行的一项多中心研究中,采用Cox回归法确定了DMR的预测因素:结果:DMR的5年风险为9.6%。在多变量分析中,免疫抑制(HR 2.93; 95% CI: 1.70-5.05; p 6 cm [相对于≤3 cm (HR 2.77; 95% CI: 1.09-7.03; p = 0.032)]、结节转移≥5个[相对于1-2个 (HR 2.79; 95% CI: 1.63-4.78; p 结论:结节转移的DMR风险为9.6%:结节转移性HNcSCC的DMR风险随免疫抑制、结节大小>6厘米、结节转移≥5个和双侧疾病而增加。在治疗前进行简单的DMR风险评分可能对临床有用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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