Siqing Wang, Wenchao Dan, Zixuan Wang, Yujie Sun, Guangzhong Zhang
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引用次数: 0
Abstract
Objective: Oxidative stress is strongly associated with atopic dermatitis (AD), and increased antioxidant intake could potentially reduce the risk of or alleviate its symptoms. However, the argument is disputed. Therefore, we conducted a Mendelian randomization (MR) analysis to explore the causal relationship between dietary antioxidant vitamin intake and AD.
Methods: We applied MR analysis to examine the causative association between dietary antioxidant vitamin intake (vitamin C, vitamin E, carotene, and retinol) and AD. The genome-wide association study (GWAS) summary data for antioxidant vitamins intake and AD were obtained from the IEU OpenGWAS database and the UK biobank. Our study consisted of two major parts, MR analysis to detect the causal relationship between exposure and outcome, and sensitivity analysis as supplemental evidence to verify the robustness of the results.
Result: The results revealed a suggestive causal relationship between vitamin E intake and AD (p = 0.038, OR 95% CI = 0.745-0.992). However, there was no causal relationship between the other three vitamins (vitamin C, carotene, and retinol) and AD (p = 0.507, OR 95% CI = 0.826-1.099) (p = 0.890, OR 95% CI = 0.864-1.184) (p = 0.492, OR 95% CI = 0.893-1.264). None of the single nucleotide polymorphisms (SNPs) were detected as heterogeneous and pleiotropy in the sensitivity analysis (p > 0.05).
Conclusion: The analysis suggested that dietary intake of vitamin E may potentially lower the risk of AD. Conversely, intake of vitamin C, retinol, and carotene is not causally related to AD. Although vitamin E intake could be protective against AD, intake of dietary antioxidant vitamins to prevent or treat AD is not necessary.
目的:氧化应激与特应性皮炎(AD)密切相关:氧化应激与特应性皮炎(AD)密切相关,增加抗氧化剂的摄入量有可能降低患特应性皮炎的风险或减轻其症状。然而,这一观点存在争议。因此,我们进行了孟德尔随机化(MR)分析,以探讨膳食抗氧化维生素摄入量与特应性皮炎之间的因果关系:我们采用MR分析法研究了膳食中抗氧化维生素(维生素C、维生素E、胡萝卜素和视黄醇)摄入量与AD之间的因果关系。抗氧化维生素摄入量与AD的全基因组关联研究(GWAS)汇总数据来自IEU OpenGWAS数据库和英国生物库。我们的研究由两大部分组成,一是检测暴露与结果之间因果关系的MR分析,二是作为补充证据验证结果稳健性的敏感性分析:结果显示,维生素 E 摄入量与 AD 之间存在提示性因果关系(p = 0.038,OR 95% CI = 0.745-0.992)。然而,其他三种维生素(维生素 C、胡萝卜素和视黄醇)与 AD 之间没有因果关系(p = 0.507,OR 95% CI = 0.826-1.099)(p = 0.890,OR 95% CI = 0.864-1.184)(p = 0.492,OR 95% CI = 0.893-1.264)。在敏感性分析中,没有一个单核苷酸多态性(SNPs)被检测出具有异质性和多义性(P > 0.05):分析表明,从膳食中摄入维生素 E 有可能降低 AD 风险。相反,维生素 C、视黄醇和胡萝卜素的摄入量与注意力缺失症没有因果关系。虽然维生素 E 的摄入量可预防注意力缺失症,但没有必要通过摄入膳食中的抗氧化维生素来预防或治疗注意力缺失症。
期刊介绍:
Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin.
Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered.
The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.