Emerging roles of the chromatin remodeler MORC2 in cancer metabolism.

IF 2.8 4区医学 Q2 ONCOLOGY

Medical Oncology Pub Date : 2024-08-08 DOI:10.1007/s12032-024-02464-9

Bibhukalyan Mohapatra, Suresh B Pakala

引用次数: 0

Abstract

Cancer is characterized by metabolic reprogramming in cancer cells, which is crucial for tumorigenesis. The highly deregulated chromatin remodeler MORC2 contributes to cell proliferation, invasion, migration, DNA repair, and chemoresistance. MORC2 also plays a key role in metabolic reprogramming, including lipogenesis, glucose, and glutamine metabolism. A recent study showed that MORC2-regulated glucose metabolism affects the expression of E-cadherin, a crucial protein in the epithelial-to-mesenchymal transition. This review discusses recent developments in MORC2 regulated cancer cell metabolism and its role in cancer progression.

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染色质重塑剂 MORC2 在癌症代谢中的新作用。

癌症的特点是癌细胞的代谢重编程，这对肿瘤的发生至关重要。高度失调的染色质重塑因子 MORC2 对细胞增殖、侵袭、迁移、DNA 修复和化疗抗性起着重要作用。MORC2 还在新陈代谢重编程（包括脂肪生成、葡萄糖和谷氨酰胺代谢）中发挥关键作用。最近的一项研究表明，MORC2-调控的葡萄糖代谢会影响E-cadherin的表达，而E-cadherin是上皮细胞向间质转化过程中的一种关键蛋白。本综述将讨论 MORC2 调控癌细胞代谢的最新进展及其在癌症进展中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Oncology 医学-肿瘤学

CiteScore

4.20

自引率

2.90%

发文量

259

审稿时长

1.4 months

期刊介绍： Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.