The KERATO Biomechanics Study 1: A Comparative Evaluation Using Brillouin Microscopy and Dynamic Scheimpflug Imaging.

IF 2.9 3区 医学 Q1 OPHTHALMOLOGY
Riccardo Vinciguerra, Sara Palladino, Robert Herber, Mario R Romano, Paolo Vinciguerra
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引用次数: 0

Abstract

Purpose: To assess the corneal biomechanical properties in normal individuals and patients with keratoconus using the Brillouin optical scanning system (Intelon Optics) (BOSS) and compare them with ultra-high-speed Scheimpflug imaging (Corvis ST; Oculus Optikgeräte GmbH).

Methods: Sixty eyes from 60 patients (30 normal and 30 keratoconus) were included in this prospective, single-center, comparative, non-interventional study. Corneal biomechanics were evaluated using the Corvis ST and the BOSS. With the BOSS, each corneal image was acquired three times, measuring 10 locations within an 8-mm diameter. Parameters extracted included mean, maximum, and minimum Brillouin shift. These 10 points were also grouped into superior, central, and inferior regions. BOSS repeatability was assessed using the coefficient of repeatability and coefficient of variation. Furthermore, normal individuals and patients with keratoconus were compared using the Corvis ST and BOSS.

Results: The BOSS exhibited good repeatability, with coefficient of repeatability ranging from 0.098 to 0.138 GHz for single points in normal individuals and 0.096 to 0.149 GHz for patients with keratoconus. Statistical analysis revealed significant differences between normal individuals and patients with keratoconus, indicating softer corneas in keratoconus, observed with both the Corvis ST and BOSS. Specifically, the BOSS showed significant differences in mean, inferior, and superior mean, maximum, and minimum Brillouin frequency shift (all P < .05), whereas the Corvis ST displayed highly significant differences in stiffness parameter at first applanation, stress strain index, deformation amplitude ratio, and inverse integrated radius (all P < .001).

Conclusions: Corneal biomechanical measurements proved highly repeatable and effectively demonstrated significant differences between normal individuals and patients with keratoconus using both the BOSS and the Corvis ST. [J Refract Surg. 2024;40(8):e569-e578.].

KERATO 生物力学研究 1:使用布里渊显微镜和动态 Scheimpflug 成像进行比较评估。
目的:使用布里渊光学扫描系统(Intelon Optics)(BOSS)评估正常人和角膜病患者的角膜生物力学特性,并与超高速 Scheimpflug 成像(Corvis ST; Oculus Optikgeräte GmbH)进行比较:这项前瞻性、单中心、比较性、非干预性研究纳入了 60 名患者(30 名正常患者和 30 名角膜炎患者)的 60 只眼睛。使用 Corvis ST 和 BOSS 对角膜生物力学进行了评估。使用 BOSS,每个角膜图像采集三次,测量 8 毫米直径范围内的 10 个位置。提取的参数包括布里渊偏移的平均值、最大值和最小值。这 10 个点还被分为上部、中部和下部区域。使用重复性系数和变异系数评估 BOSS 的重复性。此外,还使用 Corvis ST 和 BOSS 对正常人和角膜炎患者进行了比较:BOSS 具有良好的重复性,正常人单点重复性系数为 0.098 至 0.138 GHz,角膜病患者单点重复性系数为 0.096 至 0.149 GHz。统计分析显示,正常人和角膜病患者之间存在显著差异,表明角膜病患者的角膜更软,这在 Corvis ST 和 BOSS 上都能观察到。具体来说,BOSS 在平均、下平均和上平均、最大和最小布里渊频移方面显示出显著差异(均为 P <.05),而 Corvis ST 在首次角膜屈光度时的硬度参数、应力应变指数、变形振幅比和反比综合半径方面显示出高度显著差异(均为 P <.001):结论:使用 BOSS 和 Corvis ST 进行的角膜生物力学测量具有高度的可重复性,能有效显示正常人和角膜炎患者之间的显著差异。[J Refract Surg. 2024;40(8):e569-e578.]。
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来源期刊
CiteScore
5.10
自引率
12.50%
发文量
160
审稿时长
4-8 weeks
期刊介绍: The Journal of Refractive Surgery, the official journal of the International Society of Refractive Surgery, a partner of the American Academy of Ophthalmology, has been a monthly peer-reviewed forum for original research, review, and evaluation of refractive and lens-based surgical procedures for more than 30 years. Practical, clinically valuable articles provide readers with the most up-to-date information regarding advances in the field of refractive surgery. Begin to explore the Journal and all of its great benefits such as: • Columns including “Translational Science,” “Surgical Techniques,” and “Biomechanics” • Supplemental videos and materials available for many articles • Access to current articles, as well as several years of archived content • Articles posted online just 2 months after acceptance.
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