Four new homoisoflavonoids from Caesalpinia pulcherrima.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-08-09 DOI:10.1080/10286020.2024.2387307

Yu-Cheng Zheng, Wen-Jian Gu, Ren-Geng Shu, Pu-Zhao Zhang

引用次数: 0

Abstract

Four new homoisoflavonoids, 7-hydroxy-3-[hydroxy(4'-methoxyphenyl)methyl]-benzopyran-4-one (1), (3R)-7, 8-dihydroxy-3-(4'-methoxybenzyl)-chroman-4-one (2), 7-hydroxy-3-(2'-hydroxy-4'-methoxybenzyl)-chroman-4-one (3), and 7-hydroxy-3-(2'-hydroxy-4'-methoxybenzyl)-benzopyran-4-one (4), were isolated from the seeds of Caesalpinia pulcherrima. The structures of new compounds were elucidated by MS and NMR spectra. Their absolute configurations were assigned using electronic circular dichroism spectrum. Compounds 2 and 4 exhibited cytotoxic effects on MCF-7/TAM cells with the IC₅₀ values of 101.4 ± 0.03 and 93.02 ± 0.03 μM, respectively.

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从 Caesalpinia pulcherrima 中提取的四种新的同异黄酮。

四种新的同异黄酮，7-羟基-3-[羟基(4'-甲氧基苯基)甲基]-苯并吡喃-4-酮(1)，(3R)-7, 8-二羟基-3-(4'-甲氧基苄基)-色满-4-酮(2)、7-hydroxy-3-(2'-hydroxy-4'-methoxybenzyl)-chroman-4-one (3) 和 7-hydroxy-3-(2'-hydroxy-4'-methoxybenzyl)-benzopyran-4-one (4)。质谱和核磁共振光谱阐明了新化合物的结构。利用电子圆二色光谱确定了它们的绝对构型。化合物 2 和 4 对 MCF-7/TAM 细胞具有细胞毒性作用，其 IC50 值分别为 101.4 ± 0.03 和 93.02 ± 0.03 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.