Dynamic cerebral autoregulation during repeated handgrip exercise: comparisons with spontaneous rest and sit-stand maneuvers.

IF 3.3 3区 医学 Q1 PHYSIOLOGY
Journal of applied physiology Pub Date : 2024-09-01 Epub Date: 2024-08-08 DOI:10.1152/japplphysiol.00217.2024
Wenxing Qin, Marina Fukuie, Daisuke Hoshi, Shoya Mori, Tsubasa Tomoto, Jun Sugawara, Takashi Tarumi
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Abstract

Induced arterial pressure oscillation may improve the assessment of dynamic cerebral autoregulation (dCA) with transfer function analysis (TFA). This study investigated dCA during repeated handgrip exercise (RHE) compared with spontaneous rest and sit-stand maneuvers (SSM), often used in cerebrovascular research. After a 5-min rest, 20 healthy young adults (10 women and 10 men) underwent 5 min of RHE (30% maximal voluntary contraction) and SSM at 0.05 Hz and 0.10 Hz each in random order. Power spectral density (PSD) and TFA gain, phase, coherence of mean arterial pressure (MAP), and blood velocity in the middle cerebral artery (MCAvmean) were measured in very low (VLF: 0.02-0.07 Hz) and low (LF: 0.07-0.20 Hz) frequencies. End-tidal CO2 (EtCO2) was continuously recorded throughout data collection. Compared with rest, RHE increased the PSD of MAP and MCAvmean in VLF (444% and 273%, respectively) and LF (1,571% and 1,765%, respectively) (all P < 0.001). Coherence increased during RHE (VLF: 131%, LF: 128%) and SSM (VLF: 166%, LF: 136%) compared with rest (all P < 0.05). TFA gain and phase were similar between RHE and rest, but VLF gain was higher, whereas VLF and LF phases were lower during SSM than RHE (all P < 0.05). EtCO2 was higher during SSM than rest and RHE (both P < 0.05), with the individual EtCO2 changes positively correlated with VLF gain (r = 0.538, P < 0.001). These results indicate that RHE significantly increases arterial pressure oscillation and TFA coherence and may improve dCA assessment in individuals unable to perform repeated postural changes.NEW & NOTEWORTHY This is the first study investigating dynamic cerebral autoregulation (dCA) during light-intensity repeated handgrip exercise (RHE) compared with rest and sit-stand maneuvers (SSM) using transfer function analysis (TFA). Compared with rest, RHE significantly increased oscillations of arterial blood pressure and cerebral blood velocity and coherence, whereas SSM exhibited the highest oscillations and coherence. These findings suggest that RHE may serve as an alternative method for assessing dCA in individuals unable to perform repeated postural changes.

重复握手运动时的动态脑自主调节:与自发休息和坐立动作的比较。
基于传递函数分析(TFA)的动态脑自动调节(dCA)评估可通过诱导动脉压振荡得到改善。本研究调查了重复手握运动(RHE)期间的动态脑自律调节,并将其与通常用于动态脑自律调节评估的自发休息和坐立运动(SSM)进行了比较。在休息 5 分钟后,20 名健康的年轻成年人(10 名女性)以 0.05 Hz 和 0.10 Hz 的随机顺序进行了 5 分钟的 RHE 和 SSM。比较了极低频(VLF:0.02-0.07 Hz)和低频(LF:0.07-0.20 Hz)的功率谱密度(PSD)、TFA 增益、相位以及平均动脉压(MAP)和大脑中动脉血流速度(MCAvmean)的相干性。整个研究过程都记录了潮气末二氧化碳(EtCO2)。与静息时相比,RHE 增加了 VLF(分别为 444% 和 273%)和 LF(分别为 1571% 和 1765%)中 MAP 和 MCAvmean 的 PSD,并显著提高了 TFA 相干性(VLF:131%,LF:128%),而 SSM 显示出最高的 PSD 和相干性值(所有 P <0.05)。RHE 和静息时的 TFA 增益和相位相似,但 SSM 期间 VLF 增益更高,而 VLF 和 LF 相位低于 RHE(所有 P <0.05)。在 SSMs 期间,EtCO2 比静息和 RHE 期间更高(均 P <0.05),单个变化与 VLF 增益变化呈正相关(R2 = 0.289,P <0.001)。这些结果表明,RHE 可明显增加动脉压振荡和 TFA 相干性,并可改善无法进行重复体位改变的个体的 dCA 评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.00
自引率
9.10%
发文量
296
审稿时长
2-4 weeks
期刊介绍: The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.
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