Single-cell sequencing has revealed a more complex array of thymic epithelial cells

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-08-06 DOI:10.1016/j.imlet.2024.106904

Eleonora Pardini , Serena Barachini , Greta Alì , Gisella Sardo Infirri , Irene Sofia Burzi , Marina Montali , Iacopo Petrini

{"title":"Single-cell sequencing has revealed a more complex array of thymic epithelial cells","authors":"Eleonora Pardini , Serena Barachini , Greta Alì , Gisella Sardo Infirri , Irene Sofia Burzi , Marina Montali , Iacopo Petrini","doi":"10.1016/j.imlet.2024.106904","DOIUrl":null,"url":null,"abstract":"<div><p>Thymic epithelial cells participate in the maturation and selection of T lymphocytes. This review explores recent insights from single-cell sequencing regarding classifying thymic epithelial cells in both normal and neoplastic thymus. Cortical thymic epithelial cells facilitate thymocyte differentiation and contribute to positive selection. Medullary epithelial cells are distinguished by their expression of AIRE. Cells progress from a pre-AIRE state, containing precursors with cortical and medullary characteristics, termed junctional cells. Mature medullary epithelial cells exhibit promiscuous gene expression and after that downregulate AIRE mRNA. Post-AIRE cells can adopt a Hassall corpuscle-like phenotype or exhibit distinctive differentiation characteristics including tuft cells, ionocytes, neuroendocrine cells, and myoid cells.</p></div>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165247824000786/pdfft?md5=cad9988cf468c15dbb499bdc23606c93&pid=1-s2.0-S0165247824000786-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165247824000786","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}

引用次数: 0

Abstract

Thymic epithelial cells participate in the maturation and selection of T lymphocytes. This review explores recent insights from single-cell sequencing regarding classifying thymic epithelial cells in both normal and neoplastic thymus. Cortical thymic epithelial cells facilitate thymocyte differentiation and contribute to positive selection. Medullary epithelial cells are distinguished by their expression of AIRE. Cells progress from a pre-AIRE state, containing precursors with cortical and medullary characteristics, termed junctional cells. Mature medullary epithelial cells exhibit promiscuous gene expression and after that downregulate AIRE mRNA. Post-AIRE cells can adopt a Hassall corpuscle-like phenotype or exhibit distinctive differentiation characteristics including tuft cells, ionocytes, neuroendocrine cells, and myoid cells.

查看原文本刊更多论文

单细胞测序揭示了胸腺上皮细胞更为复杂的排列。

胸腺上皮细胞参与 T 淋巴细胞的成熟和选择。这篇综述探讨了单细胞测序对正常胸腺和肿瘤胸腺胸腺上皮细胞分类的最新见解。皮质胸腺上皮细胞可促进胸腺细胞分化并有助于正向选择。髓质上皮细胞因表达 AIRE 而与众不同。细胞从前 AIRE 状态发展而来，包含具有皮质和髓质特征的前体细胞，称为交界细胞。成熟的髓质上皮细胞表现出杂乱的基因表达，之后下调 AIRE mRNA。后 AIRE 细胞可采用 Hassall 冠状细胞样表型，或表现出独特的分化特征，包括丛细胞、离子细胞、神经内分泌细胞和肌样细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567