Nonlinear association between the triglyceride-glucose index and diabetes mellitus in overweight and obese individuals: a cross-sectional retrospective analysis.

IF 3.4 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Yongbing Sun, Yuang Gu, Yang Zhou, Ao Liu, Xinbei Lin, Xuan Wang, Yawei Du, Xue Lv, Jing Zhou, Zhonglin Li, Xiaoling Wu, Zhi Zou, Shewei Dou, Michael Zhang, Jiadong Zhu, Feifei Shang, Fengli Li, Yangxi Hu, Hao Li, Yongli Li
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引用次数: 0

Abstract

Background: The triglyceride-glucose (TyG) index is linked to both the development and progression of diabetes, while obesity remains a significant risk factor for this disease. However, the relationship between the TyG index and overweight or obese diabetes remains unclear.

Methods: This study was a cross-sectional analysis of data from 40,633 participants with body mass index (BMI) ≥ 24 kg/m2 who were screened from January 2018 to December 2023 at Henan Provincial People's Hospital. Participants were divided into groups of overweight or obese individuals with diabetes and those without diabetes according to the diabetes diagnostic criteria. The TyG index, the dependent variable, was determined using the equation ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. We explored the association between TyG index and diabetes in overweight or obese individuals through multivariate logistic regression, subgroup analysis, generalized additive models, smoothed curve fitting, and analysis of threshold effects.

Results: Patients who were overweight or obese and had diabetes had higher TyG index levels than those without diabetes. After adjusting for confounders, our findings indicated a significant association between the TyG index and the risk of diabetes in overweight or obese individuals [odds ratio (OR) = 7.38, 95% confidence interval (CI): 6.98-7.81]. There was a J-shaped nonlinear association between TyG index and diabetes. When TyG index was > 4.46, the risk of diabetes increased sharply. Notably, a high baseline TyG index (Q4 group) correlated with a notably greater risk of diabetes than did the Q1 group, with an OR of 22.72 (95% CI: 20.52-25.16). Subgroup analysis revealed that the association between TyG and diabetes was stronger in females than in males (OR = 7.57, 95% CI: 6.76-8.48,), more significant in individuals with a BMI of 24-28 kg/m2 than in those with a BMI ≥ 28 kg/m2 (OR = 8.40, 95% CI: 7.83-9.02), and increased with age (OR = 8.15, 95% CI: 7.25-9.17) (all P for interaction < 0.001).

Conclusion: Among overweight or obese individuals, a higher TyG index is associated with an elevated risk of diabetes, especially when TyG is > 4.46. Furthermore, factors such as sex, age, and BMI significantly influence the risk of diabetes in overweight or obese individuals. Specifically, older women with a BMI of 24-28 kg/m2 are at a greater risk of diabetes under similar TyG index conditions.

超重和肥胖者的甘油三酯-葡萄糖指数与糖尿病之间的非线性关系:横断面回顾性分析。
背景:甘油三酯-葡萄糖(TyG)指数与糖尿病的发生和发展有关,而肥胖仍然是糖尿病的一个重要风险因素。然而,TyG指数与超重或肥胖糖尿病之间的关系仍不清楚:本研究对河南省人民医院于2018年1月至2023年12月筛查的40633名体重指数(BMI)≥24 kg/m2的参与者的数据进行横断面分析。根据糖尿病诊断标准,参与者被分为患有糖尿病的超重或肥胖者组和未患有糖尿病的超重或肥胖者组。因变量TyG指数采用ln[空腹甘油三酯(mg/dL)×空腹血糖(mg/dL)/2]公式确定。我们通过多变量逻辑回归、亚组分析、广义加性模型、平滑曲线拟合和阈值效应分析,探讨了超重或肥胖者的TyG指数与糖尿病之间的关系:结果:超重或肥胖且患有糖尿病的患者的TyG指数水平高于未患糖尿病的患者。在对混杂因素进行调整后,我们的研究结果表明,超重或肥胖者的TyG指数与糖尿病风险之间存在显著关联[比值比(OR)=7.38,95%置信区间(CI):6.98-7.81]。TyG指数与糖尿病之间呈 "J "形非线性关系。当TyG指数大于4.46时,患糖尿病的风险急剧增加。值得注意的是,基线TyG指数高(Q4组)的糖尿病风险明显高于Q1组,OR值为22.72(95% CI:20.52-25.16)。亚组分析显示,TyG 与糖尿病的相关性在女性中比在男性中更强(OR = 7.57,95% CI:6.76-8.48),在体重指数为 24-28 kg/m2 的个体中比在体重指数≥ 28 kg/m2 的个体中更显著(OR = 8.40,95% CI:7.83-9.02),并且随着年龄的增长而增加(OR = 8.15,95% CI:7.25-9.17)(所有 P 均为交互作用结论):在超重或肥胖人群中,TyG指数越高,患糖尿病的风险越高,尤其是当TyG>4.46时。此外,性别、年龄和体重指数等因素对超重或肥胖者的糖尿病风险也有显著影响。具体而言,体重指数为 24-28 kg/m2 的老年妇女在类似 TyG 指数条件下患糖尿病的风险更大。
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来源期刊
Diabetology & Metabolic Syndrome
Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-
CiteScore
6.20
自引率
0.00%
发文量
170
审稿时长
7.5 months
期刊介绍: Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.
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