Metabolic syndrome is associated with mortality in elderly patients with acute respiratory distress syndrome.

IF 3.4 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Xiao Xu, Huajuan Xu, Ming Li, Shuying Yan, Huilin Chen
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Abstract

Background: This study aims to evaluate the association of metabolic syndrome (MetS) with the risk of all-cause mortality in elderly patients with acute respiratory distress syndrome (ARDS).

Methods: Elderly ARDS patients (≥ 65 years) enrolled from our hospital between January 2018 and July 2023 were divided into the MetS group or the non-MetS group. The outcomes were 28-day and 90-day all-cause mortality rates in the total population and two subgroups stratified by age (65-75 years and ≥ 75 years). Multivariate Cox regression was employed to assess the association of MetS with all-cause mortality, after controlling for potential cofounding factors.

Results: A total of 946 patients were divided into the MetS group (n = 410) or the non-MetS group (n = 536). The 28-day and 90-day all-cause mortality rates were significantly higher for MetS group compared to non-MetS group in the total population and two subgroups (all P < 0.01). Multivariate Cox regression indicated that MetS was significantly associated with a higher risk of 90-day all-cause mortality in the total population (HR = 1.62, 95% CI: 1.22-2.15; P < 0.01), and subgroups of patients aged 65-75 years (HR = 1.52, 95% CI: 1.04-2.21; P = 0.03) and ≥ 75 years (HR = 1.90, 95% CI: 1.23-2.94; P < 0.01). Moreover, with each MetS criterion added from 0 to 1 to 2, 3, and 4 of 4 criteria, both 28-day and 90-day all-cause mortality rates significantly increased (both P < 0.01).

Conclusion: MetS was associated with higher risks of 28-day and 90-day all-cause mortality in elderly patients with ARDS.

代谢综合征与急性呼吸窘迫综合征老年患者的死亡率有关。
背景:本研究旨在评估代谢综合征(MetS)与急性呼吸窘迫综合征(ARDS)老年患者全因死亡风险的关系:本研究旨在评估代谢综合征(MetS)与老年急性呼吸窘迫综合征(ARDS)患者全因死亡风险的相关性:将2018年1月至2023年7月期间我院收治的老年ARDS患者(≥65岁)分为MetS组和非MetS组。结果为总人群和按年龄分层的两个亚组(65-75 岁和≥ 75 岁)的 28 天和 90 天全因死亡率。在控制了潜在的共因因素后,采用多变量 Cox 回归评估 MetS 与全因死亡率的关系:共有 946 名患者被分为 MetS 组(410 人)和非 MetS 组(536 人)。在总人群和两个亚人群中,MetS 组的 28 天和 90 天全因死亡率明显高于非 MetS 组(均为 P 结论:MetS 与更高的死亡风险相关:MetS 与 ARDS 老年患者 28 天和 90 天全因死亡率较高的风险相关。
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来源期刊
Diabetology & Metabolic Syndrome
Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-
CiteScore
6.20
自引率
0.00%
发文量
170
审稿时长
7.5 months
期刊介绍: Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.
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