Non-Breast Implantable Medical Devices and Associated Malignancies: A Systematic Review.

IF 3 2区 医学 Q1 SURGERY
Natalia Ziolkowski, John Milkovich, Alexandra D'Souza, Ryan E Austin, Patricia McGuire, Frank Lista, Jamil Ahmad
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引用次数: 0

Abstract

Innovation in healthcare has led to the development of numerous implantable medical devices (IMDs). However, advances in our knowledge of breast implant-associated malignancies have raised questions about the prevalence, etiology, and management of malignancies associated with non-breast IMDs. The objective of this study was to examine the prevalence and characteristics of malignancies associated with non-breast IMDs. An expert medical librarian developed the search strategy for this review. Databases included MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials. In addition, gray literature sources were searched, and relevant references from systematic reviews and meta-analyses were included. The PRISMA guideline was followed for the review. Risk of bias was evaluated with the JBI Critical Appraisal tools. A total of 12,230 articles were reviewed, with a total of 77 meeting inclusion criteria. Risk of bias was highest with case reports (moderate, average of 65.1% with range of 37.5% to 100%) and low for the remaining study types. In total, 616 cases of IMD-associated malignancies were identified. Malignancies associated with IMDs were reported in the head and neck (543, 88.1%), lower extremity (57, 9.6%), thorax (9, 1.4%), abdomen (3, 0.5%), and genitourinary system (2, 0.3%). The most common malignancy type in the lower extremity was sarcoma, in the head and neck was squamous cell carcinoma, and in the thorax was lymphoma. This study is the first comprehensive systematic review of its kind. Overall, the oncologic risk of IMDs is low. The discussion of malignancy is an important part of the overall consent process, and malignancy should be considered with any new signs or symptoms in the anatomic area of an implant. More data are needed to better understand how primary malignancies occur around IMDs and how to reduce this risk.

Level of evidence: 3:

非乳腺植入式医疗器械与相关恶性肿瘤:系统回顾。
医疗保健领域的创新带动了众多植入式医疗设备(IMDs)的发展。然而,随着我们对乳房植入物相关恶性肿瘤认识的不断深入,我们对非乳房植入式医疗器械相关恶性肿瘤的发病率、病因和管理提出了疑问。本研究的目的是探讨与非乳房植入物相关的恶性肿瘤的发病率和特征。一位医学图书管理员专家为本综述制定了检索策略。数据库包括 MEDLINE(马里兰州贝塞斯达国家医学图书馆;检索日期范围:1946 年至 2023 年 6 月 21 日:1946年至2023年6月21日)、EMBASE(Elsevier,荷兰阿姆斯特丹;检索日期范围:1946年至2023年6月21日):EMBASE(Elsevier,荷兰阿姆斯特丹;检索日期范围:1946 年至 2023 年 6 月 21 日)和 Cochrane Central Register of Controlled Trials(CENTRAL;Cochrane Library,Wiley,Hoboken,NJ;检索日期范围:1946 年至 2023 年 6 月 21 日):1946年至2023年6月21日)。此外,还检索了灰色文献来源,并纳入了系统综述和荟萃分析中的相关参考文献。采用 PRISMA 指南指导综述。使用 JBI 关键评估工具对偏倚风险进行了评估。共审查了 12,230 篇文章,其中 77 篇符合纳入标准。病例报告的偏倚风险最高(中度,平均为 65.1%,范围在 37.5% 到 100% 之间),其余研究类型的偏倚风险较低。总共确定了 616 例与 IMD 相关的恶性肿瘤。与 IMD 相关的恶性肿瘤报告发生在头颈部(543 例,88.1%)、下肢(57 例,9.6%)、胸部(9 例,1.4%)、腹部(3 例,0.5%)和泌尿生殖系统(2 例,0.3%)。下肢最常见的恶性肿瘤类型是肉瘤,头颈部最常见的恶性肿瘤类型是鳞状细胞癌,胸部最常见的恶性肿瘤类型是淋巴瘤。这项研究是同类研究中的首次全面系统回顾。总体而言,综合症的肿瘤风险较低。恶性肿瘤的讨论是整个同意过程的重要组成部分,植入物解剖区域出现任何新的体征或症状时都应考虑恶性肿瘤。需要更多的数据来更好地了解原发性恶性肿瘤是如何在 IMD 周围发生的,以及如何降低这种风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.20
自引率
20.70%
发文量
309
审稿时长
6-12 weeks
期刊介绍: Aesthetic Surgery Journal is a peer-reviewed international journal focusing on scientific developments and clinical techniques in aesthetic surgery. The official publication of The Aesthetic Society, ASJ is also the official English-language journal of many major international societies of plastic, aesthetic and reconstructive surgery representing South America, Central America, Europe, Asia, and the Middle East. It is also the official journal of the British Association of Aesthetic Plastic Surgeons, the Canadian Society for Aesthetic Plastic Surgery and The Rhinoplasty Society.
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