Physicochemical and biological properties of dental materials and formulations with silica nanoparticles: A narrative review

IF 4.6 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Dental Materials Pub Date : 2024-11-01 DOI:10.1016/j.dental.2024.07.028

Larissa Pavanello , Iago Torres Cortês , Rafaela Durrer Parolina de Carvalho , Mayara Zaghi Dal Picolo , Vanessa Cavalli , Larissa Tavares Sampaio Silva , Letícia Cristina Cidreira Boaro , Polina Prokopovich , Karina Cogo-Müller

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引用次数: 0

Abstract

Objective

Silica nanoparticles (SNPs) have been extensively studied and used in different dental applications to promote improved physicochemical properties, high substance loading efficiency, in addition to sustained delivery of substances for therapeutic or preventive purposes. Therefore, this study aimed to review the SNPs applications in nanomaterials and nanoformulations in dentistry, discussing their effect on physicochemical properties, biocompatibility and ability to nanocarry bioactive substances.

Data resources

Literature searches were conducted on PubMed, Web of Science, and Scopus databases to identify studies examining the physicochemical and biological properties of dental materials and formulations containing SNPs. Data extraction was performed by one reviewer and verified by another

Study selection

A total of 50 were reviewed. In vitro studies reveal that SNPs improved the general properties of dental materials and formulations, such as microhardness, fracture toughness, flexural strength, elastic modulus and surface roughness, in addition to acting as efficient nanocarriers of substances, such as antimicrobial, osteogenic and remineralizing substances, and showed biocompatibility

Conclusions

SNPs are biocompatible, improve properties of dental materials and serve as effective carriers for bioactive substances

Clinical significance

Overall, SNPs are a promising drug delivery system that can improve dental materials biological and physicochemical and aesthetic properties, increasing their longevity and clinical performance. However, more studies are needed to elucidate SNPs short- and long-term effects in the oral cavity, mainly on in vivo and clinical studies, to prove their effectiveness and safety.

查看原文本刊更多论文

含纳米二氧化硅的牙科材料和配方的物理化学和生物学特性：综述。

目的：二氧化硅纳米颗粒（SNPs）已被广泛研究并应用于不同的牙科领域，以改善理化特性、提高物质负载效率，并持续输送物质用于治疗或预防目的。因此，本研究旨在回顾 SNPs 在牙科纳米材料和纳米制剂中的应用，讨论其对理化特性、生物相容性和纳米载入生物活性物质能力的影响：在PubMed、Web of Science和Scopus数据库中进行文献检索，以确定对含有SNPs的牙科材料和制剂的物理化学和生物特性进行研究的情况。数据提取工作由一名审稿人完成，并由另一名审稿人核实。体外研究表明，SNPs 可改善牙科材料和配方的一般特性，如微硬度、断裂韧性、抗弯强度、弹性模量和表面粗糙度，此外还可作为抗菌、成骨和再矿化物质等物质的高效纳米载体，并具有生物相容性结论：SNPs 具有良好的生物相容性：临床意义：总的来说，SNP 是一种很有前景的给药系统，可以改善牙科材料的生物、理化和美学特性，延长其使用寿命，提高临床表现。然而，还需要更多的研究来阐明 SNP 在口腔中的短期和长期效应，主要是体内和临床研究，以证明其有效性和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dental Materials 工程技术-材料科学：生物材料

CiteScore

9.80

自引率

10.00%

发文量

290

审稿时长

67 days

期刊介绍： Dental Materials publishes original research, review articles, and short communications. Academy of Dental Materials members click here to register for free access to Dental Materials online. The principal aim of Dental Materials is to promote rapid communication of scientific information between academia, industry, and the dental practitioner. Original Manuscripts on clinical and laboratory research of basic and applied character which focus on the properties or performance of dental materials or the reaction of host tissues to materials are given priority publication. Other acceptable topics include application technology in clinical dentistry and dental laboratory technology. Comprehensive reviews and editorial commentaries on pertinent subjects will be considered.