Causal Association Between Type 2 Diabetes Mellitus and Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.

IF 2.8 Q2 NEUROSCIENCES

Journal of Alzheimer's disease reports Pub Date : 2024-06-18 eCollection Date: 2024-01-01 DOI:10.3233/ADR-240053

Cong Li, Haifeng Qian, Lina Feng, Mingquan Li

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Abstract

Background: There is now increasing evidence that type 2 diabetes mellitus (T2DM) is associated with Alzheimer's disease (AD). However, it is unclear whether the two are causally related.

Objective: To reveal the causal association between T2DM and AD, we performed a bidirectional Mendelian randomization (MR) analysis.

Methods: Genetic instrumental variables were systematically screened, and inverse-variance weighting, MR-Egger regression, weighted median, simple mode, and weighted mode were applied to assess the pathogenic associations between the two diseases, and sensitivity analyses were used to further validate the robustness of the results.

Results: The results of forward MR analysis with T2DM as the exposure were [OR = 0.998, 95% CI (0.975∼1.021), p = 0.857], and the results of reverse MR analysis with AD as the exposure were [OR = 0.966, 95% CI (0.934∼0.999), p = 0.043]. The results showed no significant association between T2DM and AD at the gene level (p < 0.025). Sensitivity analyses were consistent with the results of the main analysis, confirming the robustness of the study.

Conclusions: T2DM and AD may not be genetically causally associated.

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2 型糖尿病与阿尔茨海默病之间的因果关系：双样本孟德尔随机研究

背景：现在有越来越多的证据表明，2型糖尿病（T2DM）与阿尔茨海默病（AD）有关。然而，二者是否存在因果关系尚不清楚：为了揭示 T2DM 与 AD 之间的因果关系，我们进行了双向孟德尔随机化（MR）分析：方法：系统筛选遗传工具变量，应用逆方差加权、MR-Egger回归、加权中位数、简单模式和加权模式评估两种疾病之间的致病关联，并采用敏感性分析进一步验证结果的稳健性：以 T2DM 为暴露因子的正向 MR 分析结果为[OR = 0.998，95% CI (0.975∼1.021)，p = 0.857]；以 AD 为暴露因子的反向 MR 分析结果为[OR = 0.966，95% CI (0.934∼0.999)，p = 0.043]。结果表明，T2DM 与 AD 在基因水平上没有明显的关联（P 结论：T2DM 与 AD 的关系可能与基因无关：T2DM和AD在基因上可能没有因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's disease reports

CiteScore

2.80

自引率

0.00%

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