Hypofractionated radiation therapy alone for human papillomavirus-related oropharyngeal cancer.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-08-07 DOI:10.1002/hed.27908

Allen M Chen, Jeremy P Harris, Tjoson Tjoa, Yarah Haidar, William B Armstrong

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引用次数: 0

Abstract

Purpose: To report a single-institutional experience with hypofractionated radiation therapy alone for human papillomavirus (HPV)-positive oropharyngeal cancer.

Methods and materials: A total of 101 consecutive patients were treated by radiation therapy alone using a regimen of 66 Gy in 30 fractions (60 patients) or 70 Gy in 33 fractions (41 patients) for newly diagnosed p16-positive squamous cell carcinoma of the oropharynx. Sixty-seven patients (67%) were never smokers.

Results: The 3-year actuarial rates of overall survival, local-regional control, and progression-free survival were 94%, 93%, and 89%, respectively. Among never-smokers, the 3-year rates of overall survival and local-regional control were 98% and 100%, respectively. The grade 3+ acute toxicity rate was 21%, with the most commonly observed side effects related to mucositis.

Conclusion: Hypofractionated radiation alone resulted in excellent outcomes for patients with HPV-positive oropharyngeal cancer. A prospective clinical trial investigating this modality in the setting of de-escalation is currently underway.

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人类乳头瘤病毒相关口咽癌的单纯低分次放射治疗。

目的：报告单个机构对人乳头状瘤病毒（HPV）阳性口咽癌进行低分次放射治疗的经验：对新确诊的 p16 阳性口咽鳞状细胞癌，共对 101 例连续患者进行了单独放疗，采用 66 Gy 分 30 次放疗（60 例患者）或 70 Gy 分 33 次放疗（41 例患者）的方案。67名患者（67%）从未吸烟：3年总生存率、局部区域控制率和无进展生存率的精算率分别为94%、93%和89%。在从不吸烟者中，3年总生存率和局部区域控制率分别为98%和100%。3级以上急性毒性发生率为21%，最常见的副作用与粘膜炎有关：结论：对于HPV阳性口咽癌患者来说，单纯低分次放射治疗的疗效非常好。目前正在进行一项前瞻性临床试验，研究这种模式在降级治疗中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.