Cell factories for biosynthesis of D-glucaric acid: a fusion of static and dynamic strategies.

IF 4 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

World journal of microbiology & biotechnology Pub Date : 2024-08-08 DOI:10.1007/s11274-024-04097-6

Junping Zhou, Yinan Xue, Zheng Zhang, Yihong Wang, Anyi Wu, Xin Gao, Zhiqiang Liu, Yuguo Zheng

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Abstract

D-glucaric acid is an important organic acid with numerous applications in therapy, food, and materials, contributing significantly to its substantial market value. The biosynthesis of D-glucaric acid (GA) from renewable sources such as glucose has garnered significant attention due to its potential for sustainable and cost-effective production. This review summarizes the current understanding of the cell factories for GA production in different chassis strains, from static to dynamic control strategies for regulating their metabolic networks. We highlight recent advances in the optimization of D-glucaric acid biosynthesis, including metabolic dynamic control, alternative feedstocks, metabolic compartments, and so on. Additionally, we compare the differences between different chassis strains and discuss the challenges that each chassis strain must overcome to achieve highly efficient GA productions. In this review, the processes of engineering a desirable cell factory for highly efficient GA production are just like an epitome of metabolic engineering of strains for chemical biosynthesis, inferring general trends for industrial chassis strain developments.

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D-葡糖酸生物合成的细胞工厂：静态和动态策略的融合。

D-葡糖酸是一种重要的有机酸，在治疗、食品和材料等领域有着广泛的应用，为其巨大的市场价值做出了重要贡献。从葡萄糖等可再生资源中生物合成 D-葡糖酸（GA）因其可持续和具有成本效益的生产潜力而备受关注。本综述总结了目前对不同底盘菌株生产 GA 的细胞工厂的了解，包括调节其代谢网络的静态和动态控制策略。我们重点介绍了优化 D-葡糖酸生物合成的最新进展，包括代谢动态控制、替代原料、代谢区等。此外，我们还比较了不同基质菌株之间的差异，并讨论了每种基质菌株要实现高效生产 GA 所必须克服的挑战。在这篇综述中，高效生产 GA 的理想细胞工厂的工程过程就像是化学生物合成菌株代谢工程的缩影，从而推断出工业基质菌株开发的总体趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World journal of microbiology & biotechnology 工程技术-生物工程与应用微生物

CiteScore

6.30

自引率

2.40%

发文量

257

审稿时长

2.5 months

期刊介绍： World Journal of Microbiology and Biotechnology publishes research papers and review articles on all aspects of Microbiology and Microbial Biotechnology. Since its foundation, the Journal has provided a forum for research work directed toward finding microbiological and biotechnological solutions to global problems. As many of these problems, including crop productivity, public health and waste management, have major impacts in the developing world, the Journal especially reports on advances for and from developing regions. Some topics are not within the scope of the Journal. Please do not submit your manuscript if it falls into one of the following categories: · Virology · Simple isolation of microbes from local sources · Simple descriptions of an environment or reports on a procedure · Veterinary, agricultural and clinical topics in which the main focus is not on a microorganism · Data reporting on host response to microbes · Optimization of a procedure · Description of the biological effects of not fully identified compounds or undefined extracts of natural origin · Data on not fully purified enzymes or procedures in which they are applied All articles published in the Journal are independently refereed.