Antidiarrheal, anti-inflammatory and antioxidant effects of Anethum graveolens L. fruit extract on castor oil-induced diarrhea in rats.

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY

Neurogastroenterology and Motility Pub Date : 2024-11-01 Epub Date: 2024-08-08 DOI:10.1111/nmo.14892

Chirine Brinsi, Saber Jedidi, Houcem Sammari, Houcine Selmi, Hichem Sebai

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引用次数: 0

Abstract

Background: Between food and medicine, nutraceuticals are widely used in human health for the prevention and treatment of various diseases. This study aims to determine the cytoprotective effects of Anethum gravelons fruit extract (AGFAE) on castor oil-induced diarrhea in rats due to its phytochemical and antioxidant properties.

Methods: Male rats were divided into six groups of six animals each: Control (C), Castor oil (CO), CO + different doses of AGFAE (50, 100, and 200 mg/kg, b.w., p.o.), and the CO + loperamide group (LOP, 10 mg/kg, b.w., p.o.).

Key results: In vitro, the chemical composition of aqueous Dill fruit extract showed strong antioxidant activity, with a high content of total polyphenols, flavonoids, and tannins. In our in vivo studies, pre-treatment with AGFAE reduced malondialdehyde and hydrogen peroxide levels and maintained normal activity of enzymatic and non-enzymatic antioxidants in the gastric and intestinal mucosa. In addition, we found that AGFAE prophylaxis improved the stability of many plasma biochemical parameters altered by castor oil intoxication, such as C-reactive protein concentrations and alkaline phosphatase activities.

Conclusions & inferences: We suggest that AGFAE phenolic compounds had significant protection against diarrhea involving several mechanisms such as reducing hypersecretion, peristaltic, inflammation, and preserving the endogenous antioxidant levels.

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Anethum graveolens L. 果实提取物对蓖麻油诱发的大鼠腹泻的止泻、抗炎和抗氧化作用

背景：在食品和药品之间，营养保健品被广泛用于人类健康，以预防和治疗各种疾病。本研究旨在确定芒果提取物（AGFAE）的植物化学和抗氧化特性对蓖麻油诱导的大鼠腹泻的细胞保护作用：雄性大鼠分为六组，每组六只：对照组（C）、蓖麻油组（CO）、CO + 不同剂量的 AGFAE 组（50、100 和 200 mg/kg，体重，口服）以及 CO + 洛哌丁胺组（LOP，10 mg/kg，体重，口服）：主要结果：在体外，莳萝果实水提取物的化学成分显示出很强的抗氧化活性，其中含有大量的总多酚、类黄酮和单宁酸。在我们的体内研究中，AGFAE 的预处理降低了丙二醛和过氧化氢的水平，并保持了胃肠粘膜中酶和非酶抗氧化剂的正常活性。此外，我们还发现，AGFAE 预防剂改善了许多因蓖麻油中毒而改变的血浆生化指标的稳定性，如 C 反应蛋白浓度和碱性磷酸酶活性：我们认为，AGFAE酚类化合物对腹泻有显著的保护作用，这涉及多种机制，如减少高分泌、蠕动、炎症和保护内源性抗氧化剂水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurogastroenterology and Motility 医学-临床神经学

CiteScore

7.80

自引率

8.60%

发文量

178

审稿时长

3-6 weeks

期刊介绍： Neurogastroenterology & Motility (NMO) is the official Journal of the European Society of Neurogastroenterology & Motility (ESNM) and the American Neurogastroenterology and Motility Society (ANMS). It is edited by James Galligan, Albert Bredenoord, and Stephen Vanner. The editorial and peer review process is independent of the societies affiliated to the journal and publisher: Neither the ANMS, the ESNM or the Publisher have editorial decision-making power. Whenever these are relevant to the content being considered or published, the editors, journal management committee and editorial board declare their interests and affiliations.