White matter hyperintensity shape is related to long-term progression of cerebrovascular disease in community-dwelling older adults.

IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Jasmin Annica Kuhn-Keller, Sigurdur Sigurdsson, Lenore J Launer, Mark A van Buchem, Matthias Jp van Osch, Vilmundur Gudnason, Jeroen de Bresser
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Abstract

White matter hyperintensity (WMH) shape is associated with long-term dementia risk in community-dwelling older adults, however, the underlying structural correlates of this association are unknown. We therefore aimed to investigate the association between baseline WMH shape and cerebrovascular disease progression over time in community-dwelling older adults. The association of WMH shape and cerebrovascular disease markers was investigated using linear and logistic regression models in the Age, Gene/Environment Susceptibility-Reykjavik (AGES) study (n = 2297; average time to follow-up: 5.2 years). A more irregular shape of periventricular/confluent WMH at baseline was associated with a larger increase in WMH volume, and with occurrence of new subcortical infarcts, new microbleeds, new enlarged perivascular spaces, and new cerebellar infarcts at the 5.2-year follow-up (all p < 0.05). Furthermore, less elongated and more irregularly shaped deep WMHs were associated with a larger increase in WMH volume, and new cortical infarcts at follow-up (p < 0.05). A less elongated shape of deep WMH was associated with new microbleeds at follow-up (p < 0.05). Our findings show that WMH shape may be indicative of the type of cerebrovascular disease marker progression. This underlines the significance of WMH shape to aid in the assessment of cerebrovascular disease progression.

白质高密度形状与社区老年人脑血管疾病的长期进展有关。
在社区居住的老年人中,白质高密度(WMH)形状与长期痴呆症风险有关,但这种关联的潜在结构相关性尚不清楚。因此,我们旨在研究社区居住的老年人的基线WMH形状与脑血管疾病随时间进展之间的关系。在年龄、基因/环境易感性-雷克雅未克(AGES)研究(n = 2297;平均随访时间:5.2 年)中,我们使用线性和逻辑回归模型研究了 WMH 形态与脑血管疾病标志物之间的关系。基线时脑室周围/弥漫性 WMH 的形状更不规则与 WMH 体积的增大以及 5.2 年随访时新的皮层下梗死、新的微出血、新的扩大的血管周围间隙和新的小脑梗死的发生有关(所有 P
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来源期刊
Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢
CiteScore
12.00
自引率
4.80%
发文量
300
审稿时长
3 months
期刊介绍: JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.
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