CADD Methods for Developing Novel Compounds Synthesized to Inhibit Tyrosine Kinase Receptors.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2024-08-07 DOI:10.2174/0115680266312422240712053821

Amal Bouribab, Abdelkbir Errougui, Samir Chtita

引用次数: 0

Abstract

Growth factors and their receptor tyrosine kinases play a central role in regulating vital cellular processes such as proliferation, differentiation, division, and cell survival, and they are closely associated with the development of various types of cancer, particularly in the context of angiogenesis. Although several small chemical compounds targeting tyrosine kinase receptors have been approved by the FDA for cancer treatment by inhibiting angiogenesis, there is still a need for more effective medications. in silico studies are now crucial tools for the design of new drugs, offering considerable advantages such as cost and time reduction. In this review, we examined recent in silico research carried out between 2022 and 2024, focusing on new drug candidates synthesized to fight cancer, in particular by targeting tyrosine kinase receptors involved in the process of angiogenesis.

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开发合成抑制酪氨酸激酶受体的新型化合物的 CADD 方法。

生长因子及其受体酪氨酸激酶在调节增殖、分化、分裂和细胞存活等重要细胞过程中发挥着核心作用，它们与各种癌症的发展密切相关，尤其是在血管生成方面。虽然美国食品和药物管理局已批准了几种以酪氨酸激酶受体为靶点的小分子化合物，用于通过抑制血管生成治疗癌症，但仍需要更有效的药物。硅学研究是目前设计新药的重要工具，具有成本低、时间短等显著优势。在这篇综述中，我们回顾了2022年至2024年期间开展的最新硅学研究，重点关注为抗击癌症而合成的候选新药，特别是通过靶向参与血管生成过程的酪氨酸激酶受体而合成的候选新药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.