Sex-related Variations in Comorbidities in Lichen Sclerosus: A Systematic Review and Meta-Analysis.

IF 3.5 4区医学 Q1 DERMATOLOGY

Acta dermato-venereologica Pub Date : 2024-08-07 DOI:10.2340/actadv.v104.39982

Špela Šuler Baglama, Gregor B E Jemec, Jan Zmazek, Katarina Trčko

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引用次数: 0

Abstract

The comorbidities of lichen sclerosus (LS) are presumed but have not been analysed in detail. The purpose of this review was to identify evidence-based associated diseases in patients with LS and explore the potential need for sex-dependent screening protocols. A comprehensive search of the MEDLINE, Embase, and PsycINFO databases from inception to 29 February 2024 was conducted using the key search terms LS and all its synonyms. Pooled odds ratios and 95% confidence intervals of comorbidities were generated using the DerSimonian and Laird random-effects model. A total of 21 case-control studies met the inclusion criteria. Of the 75 comorbidities analysed, only 16 (21.3%) were studied in both sexes, revealing no contrasting associations based on sex. Both female and male LS patients showed significantly increased odds of common dermatological conditions (i.e., lichen planus, vitiligo, alopecia areata, atopic dermatitis, and psoriasis), various cardiovascular risk factors (i.e., essential hypertension, obesity, dyslipidaemia, diabetes mellitus, and diabetes mellitus type 2), genital warts, and hypothyroidism compared with controls. Overall, the scarcity of data currently does not support the implementation of sex-dependent screening strategies. The findings do, however, present significant associations with a range of potentially serious comorbidities, which warrants further elucidation and clinical vigilance.

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硬皮病合并症的性别差异：系统回顾与元分析》。

人们推测了硬皮病（LS）的合并症，但尚未对其进行详细分析。本综述旨在确定LS患者的循证相关疾病，并探讨是否有必要制定与性别相关的筛查方案。本研究使用关键检索词 LS 及其所有同义词对 MEDLINE、Embase 和 PsycINFO 数据库进行了全面检索，检索时间从开始至 2024 年 2 月 29 日。使用 DerSimonian 和 Laird 随机效应模型生成了合并症的汇总几率比和 95% 置信区间。共有 21 项病例对照研究符合纳入标准。在所分析的75种合并症中，只有16种（21.3%）在两性中都进行了研究，没有发现基于性别的对比关系。与对照组相比，女性和男性LS患者患常见皮肤病（即扁平苔藓、白癜风、斑秃、特应性皮炎和银屑病）、各种心血管风险因素（即原发性高血压、肥胖、血脂异常、糖尿病和2型糖尿病）、生殖器疣和甲状腺机能减退的几率都明显增加。总体而言，目前数据的稀缺性并不支持实施性别筛查策略。不过，这些研究结果确实与一系列潜在的严重并发症有重大关联，值得进一步阐明并提高临床警惕。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta dermato-venereologica 医学-皮肤病学

CiteScore

4.90

自引率

2.80%

发文量

210

审稿时长

6-12 weeks

期刊介绍： Acta Dermato-Venereologica publishes high-quality manuscripts in English in the field of Dermatology and Venereology, dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of Review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. Acta Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs.