Navigating the Fractional Calcium Dynamics of Orai Mechanism in Polar Dimensions.

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Biophysics Pub Date : 2024-12-01 Epub Date: 2024-08-08 DOI:10.1007/s12013-024-01462-y

Brajesh Kumar Jha, Vora Hardagna Vatsal, Tajinder Pal Singh

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引用次数: 0

Abstract

Calcium plays a crucial role as a second messenger in neuronal signal transduction pathways. The influx of calcium ions through various physicochemical gating channels activates neuronal calcium signaling. The Endoplasmic Reticulum (ER) is a significant intracellular structure that sequesters calcium and controls signaling through SERCA, IPR, and leak channel mechanisms. Disruption of calcium dynamics can trigger intrinsic dyshomeostasis, cell damage, and apoptosis. The present study articulates a Caputo fractional time derivative in the polar coordinate dimensions to investigate the role of nonlocal calcium-free ions in the neuron through the Orai channel, and ER fluxes, incorporating various physiological parameters. The solution was obtained through the hybrid integral transform technique for analytical form. The closed form was generated using Green's function in terms of Mainardi and Wright's functions. Our simulation uncovered the calcium concentration bandwidth of interaction with different neuronal parameters. Parameters and calcium ion synergy show normal and Alzheimer's disease-impacted interaction through different illustrations. Our simulation reveals that S100B and BAPTA have significant calcium-controlling behavior.

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在极地维度中导航 Orai 机制的分数钙动力学。

钙作为第二信使在神经元信号转导途径中发挥着至关重要的作用。钙离子通过各种理化门控通道流入，激活神经元的钙信号转导。内质网（ER）是一个重要的细胞内结构，它能螯合钙离子，并通过 SERCA、IPR 和泄漏通道机制控制信号传导。钙动力学的破坏可引发内在失衡、细胞损伤和细胞凋亡。本研究在极坐标维度上阐明了卡普托分数时间导数，以研究神经元中的非局部无钙离子通过 Orai 通道和 ER 通量的作用，并结合了各种生理参数。通过混合积分变换技术获得了解析形式的解。闭合形式是利用格林函数以 Mainardi 和 Wright 函数的形式生成的。我们的模拟揭示了钙离子浓度与不同神经元参数相互作用的带宽。参数和钙离子的协同作用通过不同的图解显示了正常和受阿尔茨海默病影响的相互作用。我们的模拟揭示了 S100B 和 BAPTA 具有显著的钙离子控制行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

7.5 months

期刊介绍： Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.