Sol-gel synthesis of magnesium oxide nanoparticles and their evaluation as a therapeutic agent for the treatment of osteoarthritis.

Nanomedicine (London, England) Pub Date : 2024-01-01 Epub Date: 2024-08-07 DOI:10.1080/17435889.2024.2382421

Sen Mei, Fangchao Jiang, Na Liu, Zhizi Feng, Yu Zheng, Wei Yang, Weizhong Zhang, Yingna Cui, Weiming Wang, Jin Xie, Nan Zhang

{"title":"Sol-gel synthesis of magnesium oxide nanoparticles and their evaluation as a therapeutic agent for the treatment of osteoarthritis.","authors":"Sen Mei, Fangchao Jiang, Na Liu, Zhizi Feng, Yu Zheng, Wei Yang, Weizhong Zhang, Yingna Cui, Weiming Wang, Jin Xie, Nan Zhang","doi":"10.1080/17435889.2024.2382421","DOIUrl":null,"url":null,"abstract":"Aim: We synthesized MgO NPs via sol-gel reaction and investigated them as carriers to deliver Mg2+ to the affected joint for osteoarthritis (OA).Materials & methods: The physicochemical properties of samples were characterized by transmission electron microscope (TEM), dynamic light scattering (DLS) and x-ray diffraction (XRD). The release of Mg2+ was monitored by ICP-MS. The potential cytotoxicity was evaluated using MTT assay. The efficacy and biosafety were evaluated in a rabbit OA model.Results: MgO NPs can prolong the Mg2+ release time from 0.5 h to 12 h. No significant cytotoxicity was observed when concentrations below 250 μg/ml. Intra-articular samples could effectively alleviate the degeneration and destruction of the cartilage.Conclusion: this study demonstrates the potential of MgO NPs as a safe and effective treatment of OA. Simultaneously, the size of the particles may play a significant role in influencing the therapeutic outcome.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457622/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine (London, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/17435889.2024.2382421","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/7 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: We synthesized MgO NPs via sol-gel reaction and investigated them as carriers to deliver Mg²⁺ to the affected joint for osteoarthritis (OA).Materials & methods: The physicochemical properties of samples were characterized by transmission electron microscope (TEM), dynamic light scattering (DLS) and x-ray diffraction (XRD). The release of Mg²⁺ was monitored by ICP-MS. The potential cytotoxicity was evaluated using MTT assay. The efficacy and biosafety were evaluated in a rabbit OA model.Results: MgO NPs can prolong the Mg²⁺ release time from 0.5 h to 12 h. No significant cytotoxicity was observed when concentrations below 250 μg/ml. Intra-articular samples could effectively alleviate the degeneration and destruction of the cartilage.Conclusion: this study demonstrates the potential of MgO NPs as a safe and effective treatment of OA. Simultaneously, the size of the particles may play a significant role in influencing the therapeutic outcome.

查看原文本刊更多论文

氧化镁纳米粒子的溶胶凝胶合成及其作为骨关节炎治疗剂的评估。

目的：我们通过溶胶-凝胶反应合成了氧化镁 NPs，并研究了将其作为载体将 Mg2+ 输送到受影响关节以治疗骨关节炎（OA）。材料与方法：透射电子显微镜（TEM）、动态光散射（DLS）和 X 射线衍射（XRD）对样品的理化性质进行了表征。ICP-MS 监测了 Mg2+ 的释放。使用 MTT 试验评估了潜在的细胞毒性。在兔 OA 模型中评估了药效和生物安全性。研究结果当浓度低于 250 μg/ml 时，未观察到明显的细胞毒性。关节内样本可有效缓解软骨的退化和破坏。结论：本研究表明氧化镁氧化物具有安全有效治疗 OA 的潜力。同时，颗粒的大小可能会对治疗效果产生重要影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nanomedicine (London, England)

自引率

0.00%

发文量